{"id":"W2067559790","doi":"10.1371/journal.ppat.1003446","title":"Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; St. Michael's Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Bruton's tyrosine kinase; Phagocytosis; Candida albicans; Phagosome; Microbiology; Biology; Immune system; Tyrosine kinase; Corpus albicans; Innate immune system; Cell biology; Immunology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141073,0.0003255839,0.0002762266,0.0002242784,0.0002507281,0.000375868,0.000192875,0.0003885761,0.0008637807],"category_scores_gemma":[0.00009572376,0.0001824842,0.0003376768,0.0001079311,0.0002051982,0.0002397317,0.0004354639,0.0005434365,0.000401688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003664571,"about_ca_system_score_gemma":0.0002451389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004523197,"about_ca_topic_score_gemma":0.0004328165,"domain_scores_codex":[0.9998615,0.00001659325,0.00001187201,0.0000243609,0.00002979652,0.00005580297],"domain_scores_gemma":[0.9999034,0.000009923504,0.00002715271,0.000007455931,0.00001105176,0.00004088836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002067043,0.0000238764,0.0003841639,0.00004302267,0.00000368985,0.00008816624,0.0000114555,0.00007363573,0.9979576,0.0001183337,0.00003158618,0.001057765],"study_design_scores_gemma":[0.00005407619,0.0002727078,0.02091151,0.00001615624,0.00002934335,0.001358373,0.00006064898,0.001941812,0.9710362,0.0002274039,0.004083038,0.000008866439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991789,0.005379963,0.001306308,0.0001852071,0.00003409043,0.00001850143,0.0001445716,0.00004226264,0.001100136],"genre_scores_gemma":[0.994586,0.002050087,0.001060921,0.00005666773,0.00001240754,0.00003009308,0.000217441,0.00001025388,0.001976151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008637807,"threshold_uncertainty_score":0.002889693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362776055279147,"score_gpt":0.2546290673403483,"score_spread":0.2410013067875568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}