{"id":"W2067571605","doi":"10.1016/j.smim.2012.05.001","title":"Activation induced deaminase: How much and where?","year":2012,"lang":"en","type":"review","venue":"Seminars in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Activation-induced (cytidine) deaminase; Biology; Somatic hypermutation; Cell biology; Immunoglobulin class switching; Cytidine deaminase; Epigenetics; Computational biology; Gene; Genetics; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0006088931,0.001032289,0.002809336,0.001014211,0.0002665457,0.00003854588,0.0008047704,0.003971377,0.000483343],"category_scores_gemma":[0.0001714603,0.000923116,0.0003285522,0.0005916583,0.0008061625,0.0002636935,0.0006782737,0.002722838,0.0008466692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003184952,"about_ca_system_score_gemma":0.0002648546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001715281,"about_ca_topic_score_gemma":0.00007260239,"domain_scores_codex":[0.9951782,0.001391714,0.0009401156,0.001019323,0.00005680173,0.001413899],"domain_scores_gemma":[0.9972492,0.0008523773,0.0007754039,0.001006124,0.00007477345,0.00004216388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005835081,0.0002574,0.00004258805,0.00163774,0.000620657,0.00002363035,0.0003241065,7.562191e-9,0.1325416,0.0007555747,0.001014907,0.8627235],"study_design_scores_gemma":[0.001062907,0.0003432206,0.00002944989,0.004425783,0.0004974338,0.001230563,0.0004273944,7.152044e-8,0.006948463,0.0001254927,0.9840441,0.0008651239],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01025323,0.9851313,0.000007739394,0.0001892856,0.002638271,0.0009455363,0.00003167271,0.0001346518,0.0006683453],"genre_scores_gemma":[0.01054147,0.9812077,0.00007368254,0.00003943039,0.00009907514,0.0003279411,0.0005960744,0.0001249977,0.006989643],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9830292,"threshold_uncertainty_score":0.9999313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03128470113934409,"score_gpt":0.2758584273700201,"score_spread":0.2445737262306761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}