{"id":"W2067571642","doi":"10.1177/0091270008326716","title":"The Effects of Desvenlafaxine and Paroxetine on the Pharmacokinetics of the Cytochrome P450 2D6 Substrate Desipramine in Healthy Adults","year":2008,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Desipramine; Paroxetine; Pharmacokinetics; CYP2D6; Pharmacology; Medicine; Cytochrome P450; Internal medicine; Antidepressant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009949052,0.0004255713,0.0008705242,0.0001740881,0.0001880026,0.0002507613,0.0001543472,0.0007392643,0.001063495],"category_scores_gemma":[0.00205794,0.0003289898,0.0004605365,0.000146106,0.0002995324,0.0003433462,0.0001593483,0.0005345418,0.0002269235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698262,"about_ca_system_score_gemma":0.0001664465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006738363,"about_ca_topic_score_gemma":0.001024866,"domain_scores_codex":[0.9992126,0.0004448771,0.00005595908,0.0001260864,0.0001000683,0.00006032609],"domain_scores_gemma":[0.9991894,0.0003000973,0.000187193,0.00004560682,0.00005435752,0.0002233026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6614372,0.01153255,0.1364761,0.0004367508,0.002165373,0.0006575402,0.0006531917,0.0005839542,0.06182968,0.0001469612,0.001024462,0.1230563],"study_design_scores_gemma":[0.02855525,0.3314665,0.6283804,0.00002111018,0.0008751279,0.001031884,0.0001604971,0.0009302278,0.006195723,0.000161951,0.002188615,0.00003261894],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979479,0.001314172,0.0001084082,0.00005384089,0.00002041843,0.00005194644,0.0001242349,0.000009125334,0.0003699165],"genre_scores_gemma":[0.9983304,0.0005319289,0.000329549,0.0001320334,0.00004833746,0.00005451202,0.0001840049,0.000002890354,0.0003864235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063495,"threshold_uncertainty_score":0.0052616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1405376604974933,"score_gpt":0.4776603833222849,"score_spread":0.3371227228247916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}