{"id":"W2067573318","doi":"10.1021/jo001252l","title":"Synthesis of Enantiopure 7-[3-Azidopropyl]indolizidin-2-one Amino Acid. A Constrained Mimic of the Peptide Backbone Geometry and Heteroatomic Side-Chain Functionality of the Ala-Lys Dipeptide","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Enantiopure drug; Dipeptide; Regioselectivity; Silyl ether; Reductive amination; Diastereomer; Sodium hydride; Ether; Stereoselectivity; Alkylation; Stereochemistry; Side chain; Hydrolysis; Azide; Olefin fiber; Ketone; Amino acid; Mitsunobu reaction; Silylation; Organic chemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001608027,0.0005726072,0.0003817364,0.0001951325,0.0001402605,0.0001873539,0.0004660564,0.0003071129,0.001441292],"category_scores_gemma":[0.0001128931,0.0002304738,0.0002452118,0.0001953218,0.00009808902,0.0001893569,0.0002900179,0.0004005773,0.001415464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133246,"about_ca_system_score_gemma":0.000286984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002946558,"about_ca_topic_score_gemma":0.0007061737,"domain_scores_codex":[0.9998765,0.00001655471,0.00001107474,0.00002674444,0.00003081403,0.00003818308],"domain_scores_gemma":[0.9999137,0.000004732723,0.00002140698,0.00001229954,0.00001403678,0.00003369002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057756,0.00004219916,0.00008524157,0.00007802008,0.00001249288,0.0001930848,0.0000195442,0.0002923972,0.9958967,0.0002211323,0.00007003934,0.002983378],"study_design_scores_gemma":[0.00007728029,0.0006403828,0.001353247,0.000009645045,0.00003378615,0.0005313225,0.00001708962,0.0006568752,0.9849457,0.00005004573,0.01166228,0.00002231585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706573,0.002571613,0.01470765,0.0001033949,0.0001373779,0.0002783953,0.001306404,0.0002588498,0.009978964],"genre_scores_gemma":[0.970169,0.002436218,0.01790153,0.00009457636,0.0000345148,0.0001624752,0.00137458,0.00007919472,0.007747991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441292,"threshold_uncertainty_score":0.004821658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007410764669810492,"score_gpt":0.2005950225408726,"score_spread":0.1931842578710621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}