{"id":"W2067573318","doi":"10.1021/jo001252l","title":"Synthesis of Enantiopure 7-[3-Azidopropyl]indolizidin-2-one Amino Acid. A Constrained Mimic of the Peptide Backbone Geometry and Heteroatomic Side-Chain Functionality of the Ala-Lys Dipeptide","year":2001,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Enantiopure drug; Dipeptide; Regioselectivity; Silyl ether; Reductive amination; Diastereomer; Sodium hydride; Ether; Stereoselectivity; Alkylation; Stereochemistry; Side chain; Hydrolysis; Azide; Olefin fiber; Ketone; Amino acid; Mitsunobu reaction; Silylation; Organic chemistry; Enantioselective synthesis; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007895983,0.0002194104,0.0005351091,0.00002569146,0.00009375828,0.000009187525,0.0006397341,0.0001880068,0.0002385502],"category_scores_gemma":[0.0009355524,0.0001199036,0.0004921115,0.0003095044,0.0006693255,0.000007713651,0.0002674717,0.0002747615,4.977178e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003417666,"about_ca_system_score_gemma":0.0001498852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002250303,"about_ca_topic_score_gemma":0.00001185162,"domain_scores_codex":[0.998183,0.0001439933,0.0008543593,0.0001935423,0.0004131898,0.0002119727],"domain_scores_gemma":[0.9976092,0.000202008,0.001233398,0.0006235765,0.0002509553,0.00008084505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001813379,0.0001550137,0.009136227,0.0001341096,0.0004840009,8.190332e-7,0.00004140395,0.00001110032,0.9891717,0.000002373122,0.0001176019,0.0005642872],"study_design_scores_gemma":[0.0004882462,0.00003413405,0.01034402,0.0002068252,0.0005229497,0.0002824556,0.0003500237,0.00001237378,0.9874167,0.00009153593,0.00012761,0.0001230523],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975119,0.001230582,0.0001177847,0.0007231098,0.00003787059,0.00008362167,0.0000461488,0.000002150317,0.0002468483],"genre_scores_gemma":[0.9986192,0.0007869618,0.00008811954,0.00005661385,0.0001539878,0.000001442587,0.00000305175,0.00002075222,0.0002698551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001754957,"threshold_uncertainty_score":0.4889526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007410764669810492,"score_gpt":0.2005950225408726,"score_spread":0.1931842578710621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}