{"id":"W2067574307","doi":"10.1016/j.neurobiolaging.2008.08.001","title":"Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity","year":2008,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Oxidative stress; Drosophila melanogaster; Toxicity; Biology; Longevity; Zinc toxicity; Superoxide dismutase; Cell biology; Transcription factor; Life span; Homeostasis; Reactive oxygen species; Neuron; Toxicology; Chemistry; Biochemistry; Genetics; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009226554,0.0005338612,0.0002312894,0.0004703738,0.0002068441,0.0002732143,0.0004237228,0.0004050274,0.001410427],"category_scores_gemma":[0.0001072918,0.0002228819,0.0002626918,0.0001490012,0.0002887542,0.0002144293,0.0001833052,0.0005107781,0.000313395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006557351,"about_ca_system_score_gemma":0.0002545243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002168013,"about_ca_topic_score_gemma":0.00445882,"domain_scores_codex":[0.9999235,0.000007805563,0.000008880394,0.00002395556,0.00001453933,0.00002134306],"domain_scores_gemma":[0.9998641,0.00001706518,0.0000583576,0.00001077851,0.00001016525,0.00003947407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147,0.00002288026,0.000188502,0.00003360362,0.000006981008,0.0000433403,0.00000958841,0.00005932572,0.9986135,0.00007527462,0.00007816818,0.0007217444],"study_design_scores_gemma":[0.00002974098,0.0001290924,0.004752058,0.000009056069,0.0000319265,0.0001265511,0.00004691803,0.001042779,0.9915553,0.00005251871,0.002215554,0.000008562592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929638,0.002073335,0.002017674,0.0002195557,0.00007058337,0.00002646402,0.00117579,0.000231672,0.001221054],"genre_scores_gemma":[0.9899203,0.001025908,0.002221119,0.0001034596,0.00001530646,0.0000334805,0.0009387747,0.00006380168,0.005677779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002168013,"threshold_uncertainty_score":0.004757762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000662291984205,"score_gpt":0.2255118533337115,"score_spread":0.2055052304138695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}