{"id":"W2067579208","doi":"10.1152/ajpheart.01107.2003","title":"Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload","year":2004,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"","keywords":"Internal medicine; Endocrinology; Volume overload; Ventricle; Phosphatidylinositol; Muscle hypertrophy; Isozyme; Gene expression; Inositol; Heart failure; Biology; Phospholipase C; Medicine; Chemistry; Enzyme; Gene; Signal transduction; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655703,0.0002069164,0.0005543627,0.000111714,0.0001026535,0.00001252546,0.00006182554,0.0001286589,0.000007368576],"category_scores_gemma":[0.00003992345,0.0001769873,0.0001056834,0.0001007237,0.0005351153,0.00002234433,0.00008696711,0.000197075,0.000001531955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002291298,"about_ca_system_score_gemma":0.00008372494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006201909,"about_ca_topic_score_gemma":0.000005781142,"domain_scores_codex":[0.9987636,0.0002026163,0.0002902159,0.0004000818,0.00008797066,0.0002554909],"domain_scores_gemma":[0.9993343,0.00001718224,0.0001770676,0.0001955265,0.00008019167,0.0001957678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000389744,0.00006003857,0.002140748,0.00001888536,0.00004965654,6.702732e-7,0.0001120948,0.0001151483,0.9966525,0.00002110709,0.0002043669,0.0002349845],"study_design_scores_gemma":[0.001057632,0.001378737,0.7256848,0.00005211019,0.00001884496,0.0001619798,0.0005779588,0.000005747583,0.2664535,0.0003115894,0.004060148,0.0002369177],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980851,0.001007479,0.00002568601,0.0005053074,0.0001186604,0.0002391959,0.00001019829,0.000006028193,0.000002299879],"genre_scores_gemma":[0.9978771,0.00007380919,0.0008421548,0.0008538443,0.0002792586,0.00002427032,0.00001093728,0.00001877485,0.00001984698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.730199,"threshold_uncertainty_score":0.7217334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006260268052857517,"score_gpt":0.2070825449846186,"score_spread":0.2008222769317611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}