{"id":"W2067587577","doi":"10.1074/jbc.m310821200","title":"Depletion of Endogenous Nitric Oxide Enhances Cisplatin-induced Apoptosis in a p53-dependent Manner in Melanoma Cell Lines","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute","keywords":"Nitric oxide; Cisplatin; Apoptosis; Nitric oxide synthase; Melanoma; Cancer research; Chemistry; Cell growth; Programmed cell death; Biology; Biochemistry; Endocrinology; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006346945,0.0001571854,0.0005685617,0.000125169,0.00001385779,0.000005075688,0.0001129062,0.000254074,0.0001109258],"category_scores_gemma":[0.0007575006,0.000104635,0.0001558573,0.0003010578,0.00003338528,0.00003588213,0.00001904372,0.0004356889,0.000004165342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008990121,"about_ca_system_score_gemma":0.00008200721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002297996,"about_ca_topic_score_gemma":0.000001373946,"domain_scores_codex":[0.9985122,0.00009363558,0.0007585855,0.0001650705,0.0002302827,0.0002402111],"domain_scores_gemma":[0.9989732,0.0002870663,0.0004097589,0.0001213568,0.00009989494,0.0001087437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003174398,0.0004568785,0.0723075,0.0001404362,0.000018312,0.000197683,0.00002679276,0.00001498585,0.9261149,0.000001346856,0.00001058759,0.0003930918],"study_design_scores_gemma":[0.002229443,0.0003338878,0.01375565,0.0001569918,0.00002832897,0.0004419156,0.0002110504,0.0000064284,0.9825937,0.0001027488,0.00003600932,0.0001038162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964725,0.001012954,0.00002152118,0.0000428478,0.00004453758,0.0001125758,0.000002076061,0.00000590771,0.002285125],"genre_scores_gemma":[0.9986432,0.0004341407,0.000678057,0.00005661814,0.0001090733,0.000005515958,0.000002747592,0.000008491535,0.00006213767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05855185,"threshold_uncertainty_score":0.4266891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03369648712526214,"score_gpt":0.2588323189384188,"score_spread":0.2251358318131567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}