{"id":"W2067661283","doi":"10.1007/s10549-007-9606-8","title":"Overcoming endocrine resistance in breast cancer—are signal transduction inhibitors the answer?","year":2007,"lang":"en","type":"review","venue":"Breast Cancer Research and Treatment","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Breast cancer; Endocrine system; Hormone; Estrogen receptor; Crosstalk; Signal transduction; Medicine; Hormone receptor; Cancer research; Cancer; Internal medicine; Endocrinology; Bioinformatics; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008464786,0.001021461,0.002145513,0.001025851,0.0003204562,0.001267661,0.001472612,0.001731851,0.003039801],"category_scores_gemma":[0.0008280081,0.0003793723,0.0004854507,0.001502105,0.000778406,0.001843006,0.000652442,0.003345818,0.002451846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007547318,"about_ca_system_score_gemma":0.0007843897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001101901,"about_ca_topic_score_gemma":0.002636916,"domain_scores_codex":[0.9998071,0.00003246718,0.00002434178,0.00003029147,0.00007446426,0.00003137032],"domain_scores_gemma":[0.9997399,0.000115285,0.00003213322,0.00001001877,0.00007062858,0.00003194269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000273573,0.0001435577,0.0001574158,0.005503469,0.0001125353,0.0002371543,0.00003741745,0.0005063973,0.002510428,0.005427144,0.08340464,0.9016863],"study_design_scores_gemma":[0.0001163881,0.0001551097,0.0003954581,0.0009232477,0.0001097577,0.0006679249,0.00004445151,0.0001189935,0.000664278,0.00243206,0.9943548,0.00001747101],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001607638,0.9972804,0.0002278454,0.0009741531,0.0005725251,0.000007274285,0.00002024209,0.00001472505,0.0007420595],"genre_scores_gemma":[0.0008093835,0.9968856,0.0002988163,0.0008078288,0.0003136634,0.0000122329,0.00003581187,0.000002179906,0.0008345235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003039801,"threshold_uncertainty_score":0.01016915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04171634667875367,"score_gpt":0.3742780090216047,"score_spread":0.3325616623428511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}