{"id":"W2067690613","doi":"10.1038/nature07749","title":"A hierarchical model for evolution of 23S ribosomal RNA","year":2009,"lang":"en","type":"article","venue":"Nature","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ribosome; Abiogenesis; RNA world hypothesis; RNA; Ribosomal RNA; 5.8S ribosomal RNA; Biology; Simple (philosophy); Evolutionary biology; Computational biology; Genetics; Philosophy; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009724713,0.00007227774,0.00008550871,0.00002119408,0.00003155359,0.000003837019,0.0001163621,0.0008066195,0.000003220349],"category_scores_gemma":[0.00009273259,0.0000632292,0.00009047337,0.00003253313,0.00001559711,0.0000016105,0.00001397615,0.0002013104,6.710401e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007445066,"about_ca_system_score_gemma":0.00004928585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.387971e-7,"about_ca_topic_score_gemma":0.000001392501,"domain_scores_codex":[0.9995151,0.00001550662,0.000101676,0.0001610951,0.00008468045,0.000121934],"domain_scores_gemma":[0.9996988,0.000005998919,0.00004315207,0.0001596575,0.00005852338,0.00003389702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001643197,0.00003285185,0.00001069493,0.0000078372,0.000008785268,2.031841e-7,0.00001014047,0.0001052066,0.9823081,0.01013051,0.001124739,0.006096556],"study_design_scores_gemma":[0.0003659222,0.0003413985,0.0002654066,0.00001172913,0.00001221548,0.00000341742,0.000004689113,0.005646277,0.962009,0.02764604,0.003587306,0.0001066422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6912493,0.003728577,0.30115,0.001336976,0.0001520836,0.0004432431,0.00008434253,0.0000175125,0.001837959],"genre_scores_gemma":[0.9844205,0.00001823095,0.01452716,0.0003266259,0.0001595552,0.00001040434,0.00002943516,0.000006818029,0.0005012414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2931713,"threshold_uncertainty_score":0.6221389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007232802767355916,"score_gpt":0.252992030366577,"score_spread":0.2457592275992211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}