{"id":"W2067715180","doi":"10.1523/jneurosci.1856-09.2009","title":"Age-Dependent Impairment of Spine Morphology and Synaptic Plasticity in Hippocampal CA1 Neurons of a Presenilin 1 Transgenic Mouse Model of Alzheimer's Disease","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Centre National de la Recherche Scientifique","keywords":"Presenilin; Synaptic plasticity; Long-term potentiation; Neuroscience; Neurotransmission; Biology; Neurodegeneration; Hippocampal formation; Dendritic spine; NMDA receptor; Hippocampus; Synaptic fatigue; Alzheimer's disease; Internal medicine; Medicine; Disease; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672391,0.0006819567,0.0005278941,0.0008849503,0.0002681994,0.0003409545,0.0004024749,0.0008795069,0.001796843],"category_scores_gemma":[0.000166631,0.0004316311,0.0004202774,0.0002616392,0.0003453949,0.0005073845,0.0002872608,0.001412566,0.0006695598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004769903,"about_ca_system_score_gemma":0.0002316723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208363,"about_ca_topic_score_gemma":0.001780701,"domain_scores_codex":[0.9997501,0.00001726557,0.00003525066,0.00007568959,0.00006787289,0.00005376822],"domain_scores_gemma":[0.9997053,0.00002108723,0.00009255958,0.00002811061,0.0000320393,0.0001208476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003617504,0.00014384,0.0003823933,0.00003451071,0.00001157819,0.0001676718,0.00005618521,0.00004421891,0.9978505,0.00006024914,0.00004595286,0.0008412553],"study_design_scores_gemma":[0.000130357,0.003486668,0.05533624,0.00003873181,0.0001132913,0.002179775,0.0001426375,0.001897775,0.9333785,0.0003892547,0.002876214,0.00003056887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956071,0.001240277,0.000934191,0.0001150057,0.00005172978,0.00004120264,0.0008090388,0.0001137818,0.001087614],"genre_scores_gemma":[0.9858209,0.001379964,0.001719244,0.0001206688,0.00002357627,0.0001864639,0.001128394,0.00006847205,0.009552351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001796843,"threshold_uncertainty_score":0.006011009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04389675042160039,"score_gpt":0.3192109159523889,"score_spread":0.2753141655307885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}