{"id":"W2067739240","doi":"10.1016/j.jmb.2006.06.035","title":"Two-way Interdomain Signal Transduction in Tetracycline Repressor","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"TetR; Repressor; HAMP domain; Allosteric regulation; Binding domain; DNA-binding domain; Mutant; Biophysics; Binding site; Plasma protein binding; Chemistry; Protein domain; Biology; Transcription factor; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002996469,0.0004310095,0.0003285921,0.0002267565,0.0004212471,0.000802037,0.0003804925,0.0006655555,0.0009831233],"category_scores_gemma":[0.0002570206,0.0002319627,0.0003542006,0.0001729221,0.0003344348,0.0007459689,0.0005446811,0.001080805,0.000631482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007590938,"about_ca_system_score_gemma":0.0001921947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000365116,"about_ca_topic_score_gemma":0.0004736947,"domain_scores_codex":[0.9997867,0.00003752848,0.00001180895,0.00003813889,0.00005686971,0.00006907832],"domain_scores_gemma":[0.9998123,0.00006266774,0.00003234525,0.00002804806,0.00001830781,0.00004638755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002834497,0.00007051636,0.0002273706,0.00004359411,0.000004978521,0.0001701544,0.00004915911,0.0003736158,0.9894022,0.006631094,0.0001455555,0.002598342],"study_design_scores_gemma":[0.00006635093,0.0002022128,0.002014434,0.000006965035,0.00001399479,0.000440843,0.00007904392,0.01465815,0.9789644,0.001454903,0.002062208,0.0000364868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834393,0.0005771872,0.01354054,0.0002060814,0.00005581349,0.00002564089,0.00006393711,0.0001713584,0.001920175],"genre_scores_gemma":[0.9909876,0.0002168499,0.003962351,0.00004580538,0.00001465671,0.00002868249,0.0001200213,0.00003605318,0.004588041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009831233,"threshold_uncertainty_score":0.005507648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004588393139430405,"score_gpt":0.2504065041350754,"score_spread":0.245818110995645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}