{"id":"W2067815150","doi":"10.1002/cncr.21666","title":"Phase III study of PSC‐833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95)","year":2006,"lang":"en","type":"article","venue":"Cancer","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Medicine; Doxorubicin; Vincristine; Dexamethasone; Refractory (planetary science); Urology; Chemotherapy; Toxicity; Internal medicine; Surgery; Pharmacology; Gastroenterology; Cyclophosphamide; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002070252,0.002143308,0.002341649,0.0006556801,0.0005112672,0.001313704,0.001379291,0.001654746,0.00437193],"category_scores_gemma":[0.001113481,0.0008834015,0.001909843,0.0006722446,0.001790789,0.0009148738,0.0004264485,0.004685844,0.001229982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250594,"about_ca_system_score_gemma":0.002021224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001572483,"about_ca_topic_score_gemma":0.003267993,"domain_scores_codex":[0.9992594,0.0004130172,0.00003012258,0.0001058997,0.0000591039,0.0001323836],"domain_scores_gemma":[0.9986024,0.0002458543,0.0002424225,0.0001076247,0.0000629819,0.0007387064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8843915,0.06139838,0.002805554,0.0003529073,0.001259528,0.0001341881,0.0001720942,0.00123008,0.01897293,0.0002306867,0.002054669,0.02699743],"study_design_scores_gemma":[0.7322374,0.2597637,0.004348776,0.00002014315,0.0003348006,0.0001012184,0.00003670827,0.0006998441,0.001576667,0.000135868,0.0007284058,0.00001636774],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917994,0.001739283,0.0005669641,0.0007551649,0.000239549,0.00219032,0.001083423,0.0001129911,0.001513045],"genre_scores_gemma":[0.9889008,0.001341907,0.001505253,0.001080625,0.0002879074,0.002637791,0.001876635,0.00004434335,0.002324713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00437193,"threshold_uncertainty_score":0.01462561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02670968218884696,"score_gpt":0.3250855948836098,"score_spread":0.2983759126947629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}