{"id":"W2067839238","doi":"10.1038/cgt.2011.52","title":"Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase","year":2011,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Medulloblastoma; Neural stem cell; Prodrug; Cancer research; Medicine; Stem cell; Suicide gene; In vivo; Carboxylesterase; Pharmacology; Pathology; Genetic enhancement; Biology; Enzyme; Gene; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009384176,0.000241947,0.0004081336,0.0001005773,0.0001115963,0.00001475099,0.0001067849,0.00006890213,0.0002303369],"category_scores_gemma":[6.828984e-7,0.0001877453,0.0001616392,0.0001445965,0.00008855795,0.0000792057,0.00002273066,0.00009809188,0.000001958989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001174507,"about_ca_system_score_gemma":0.00007460571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006924492,"about_ca_topic_score_gemma":0.00001599578,"domain_scores_codex":[0.9987463,0.00007128024,0.0003451516,0.0002921219,0.0002170014,0.000328084],"domain_scores_gemma":[0.9992303,0.00002106101,0.000203665,0.0003143685,0.0001022262,0.0001283755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002257478,0.0002608382,0.05718255,0.00003192243,0.000211656,0.00005508457,0.002303045,0.00006442203,0.928533,0.00001142623,0.00002070285,0.01109965],"study_design_scores_gemma":[0.002485292,0.000346363,0.01674516,0.0001165129,0.0001211833,0.00001736046,0.000253842,0.0004610092,0.9791797,0.00001901845,0.00008313854,0.0001714569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984897,0.0142213,0.00002665005,0.00003777648,0.0002874644,0.0003867083,0.00001012205,0.00004568203,0.000087252],"genre_scores_gemma":[0.9984975,0.0003553747,0.0005636634,0.0002637265,0.000182967,0.00005046964,0.000004184001,0.00005603948,0.00002607258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0506467,"threshold_uncertainty_score":0.7656031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034257493318882,"score_gpt":0.3187075449170515,"score_spread":0.2152817955851633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}