{"id":"W2067839238","doi":"10.1038/cgt.2011.52","title":"Therapeutic targeting of subdural medulloblastomas using human neural stem cells expressing carboxylesterase","year":2011,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"","keywords":"Medulloblastoma; Neural stem cell; Prodrug; Cancer research; Medicine; Stem cell; Suicide gene; In vivo; Carboxylesterase; Pharmacology; Pathology; Genetic enhancement; Biology; Enzyme; Gene; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002443302,0.0002858374,0.0002801354,0.0003469574,0.0001306727,0.0003147853,0.0001845405,0.0003042833,0.000893152],"category_scores_gemma":[0.0001233145,0.00009607198,0.000255882,0.0002236517,0.0002420085,0.0001820087,0.0001476586,0.0005777825,0.0001963007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858527,"about_ca_system_score_gemma":0.0003486004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001375806,"about_ca_topic_score_gemma":0.002314458,"domain_scores_codex":[0.9999179,0.00001052535,0.000006169695,0.00001799531,0.00002536994,0.00002206454],"domain_scores_gemma":[0.9999498,0.00001562572,0.00001160231,0.000006240775,0.000007400658,0.000009422256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001517763,0.00006767063,0.0002173403,0.0000653485,0.0000175723,0.0001218519,0.00005080205,0.0003963192,0.9909957,0.00061184,0.0001565187,0.007147165],"study_design_scores_gemma":[0.00005704063,0.0003038576,0.0006952154,0.000005019195,0.0000418525,0.0001769883,0.00003318822,0.00153298,0.9937265,0.00009540372,0.003328555,0.000003357865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814754,0.002304558,0.01243696,0.0002776303,0.0001048848,0.0001434801,0.0002955466,0.0001343309,0.002827293],"genre_scores_gemma":[0.9914793,0.00139299,0.004351047,0.00004322983,0.00001086592,0.00005551361,0.0002259045,0.00001302384,0.002428217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375806,"threshold_uncertainty_score":0.002987862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1034257493318882,"score_gpt":0.3187075449170515,"score_spread":0.2152817955851633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}