{"id":"W2067864488","doi":"10.1139/o09-126","title":"Drug resistance is affected by colocalization of P-glycoproteins in raft-like structures unexpected in eggshells of the nematode <i>Haemonchus contortus</i>","year":2010,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Efflux; Lipid raft; Colocalization; Haemonchus contortus; Xenobiotic; Cell biology; Nematode; P-glycoprotein; ATP-binding cassette transporter; Biochemistry; Membrane; Drug resistance; Transporter; Microbiology; Ecology; Multiple drug resistance; Gene; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006731571,0.0001815494,0.000109295,0.0003234871,0.0001988093,0.0002635485,0.00009292494,0.0002630313,0.0008719662],"category_scores_gemma":[0.0001205504,0.0001616507,0.0001934036,0.0001175133,0.0002160475,0.000202796,0.0002285544,0.0001982352,0.0003083889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126391,"about_ca_system_score_gemma":0.0000620573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005353987,"about_ca_topic_score_gemma":0.0005217129,"domain_scores_codex":[0.9999155,0.00001119307,0.000005741841,0.00002581269,0.00001927849,0.00002251233],"domain_scores_gemma":[0.9998826,0.00001441748,0.00005390875,0.0000090426,0.00001786502,0.00002221574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000744733,0.000007695324,0.001817127,0.00003284614,0.00001086994,0.0002435104,0.00002378782,0.00002323536,0.9970451,0.00005112757,0.00002868396,0.0006414761],"study_design_scores_gemma":[0.00001818266,0.0002079905,0.2808328,0.00002134288,0.00006887246,0.003844999,0.0002624497,0.001714005,0.709541,0.0001427351,0.003327148,0.00001855847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970059,0.0009411038,0.00101444,0.00003901397,0.000008942825,0.000007949304,0.00009495121,0.00003680039,0.0008509327],"genre_scores_gemma":[0.9979699,0.0004527772,0.0007412608,0.00002364743,0.000005285415,0.0000106043,0.0001432372,0.000009347325,0.000644005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008719662,"threshold_uncertainty_score":0.002916992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002594670981654317,"score_gpt":0.2075047612984799,"score_spread":0.2049100903168256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}