{"id":"W2067891202","doi":"10.1074/jbc.m111.336537","title":"Comparative Processing and Function of Human and Ferret Cystic Fibrosis Transmembrane Conductance Regulator","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; ΔF508; Cystic fibrosis; Biology; Chloride channel; Apical membrane; Membrane protein; Cell biology; Molecular biology; Respiratory epithelium; Epithelium; Biochemistry; Genetics; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003635996,0.0002124672,0.0002875427,0.0003464238,0.0001755076,0.0005091334,0.0002225874,0.0004002406,0.0008921296],"category_scores_gemma":[0.0004631571,0.00009701146,0.0003763836,0.0002308991,0.0001874016,0.0003679861,0.0001449234,0.0002606043,0.000424852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000512558,"about_ca_system_score_gemma":0.0001482816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008877415,"about_ca_topic_score_gemma":0.0004942868,"domain_scores_codex":[0.9997476,0.000053435,0.00003484777,0.00007411728,0.00004874671,0.00004129078],"domain_scores_gemma":[0.9998362,0.00005326024,0.00003727643,0.00002845036,0.00002812609,0.00001657499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000488897,0.00003029775,0.001256158,0.00005938844,0.00001582746,0.0001891534,0.00008937393,0.0001161328,0.9945314,0.0003284068,0.00009990085,0.002794967],"study_design_scores_gemma":[0.00003888992,0.00097121,0.05890441,0.00002814959,0.0001000946,0.006059719,0.0002967367,0.00326308,0.9175118,0.0003054006,0.01248788,0.00003268414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936479,0.003418067,0.00142859,0.0001082462,0.00002265769,0.000009850931,0.000576068,0.00002518774,0.0007634239],"genre_scores_gemma":[0.9902232,0.001971845,0.002331497,0.00009184147,0.00002085641,0.00002191217,0.00367499,0.00002676312,0.001637054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008921296,"threshold_uncertainty_score":0.003718853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05772751011964979,"score_gpt":0.3431701640683227,"score_spread":0.2854426539486729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}