{"id":"W2067931073","doi":"10.1016/j.ymthe.2005.10.018","title":"Development of Cell-Based Tuberculosis Vaccines: Genetically Modified Dendritic Cell Vaccine Is a Much More Potent Activator of CD4 and CD8 T Cells Than Peptide- or Protein-Loaded Counterparts","year":2005,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"McMaster University","keywords":"Virology; Genetically modified organism; Biology; Cytotoxic T cell; Tuberculosis vaccines; CD8; Antigen; Peptide vaccine; T cell; Tuberculosis; Immunology; Epitope; Immune system; Gene; Mycobacterium tuberculosis; Medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464194,0.0004007509,0.0003689648,0.000200268,0.00007600319,0.000330319,0.0002608792,0.0006126536,0.0007149871],"category_scores_gemma":[0.0001233735,0.0001356643,0.0002335481,0.0001858637,0.0001974238,0.0002187206,0.0001836369,0.0005990398,0.0005016089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199449,"about_ca_system_score_gemma":0.000199162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001341113,"about_ca_topic_score_gemma":0.0001446625,"domain_scores_codex":[0.9998608,0.00002233047,0.00001222422,0.00003484114,0.0000425474,0.00002717342],"domain_scores_gemma":[0.9999419,0.000009161985,0.00001546488,0.00000854514,0.00001116214,0.00001366421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004763688,0.00006299166,0.0001341426,0.00009916087,0.000005700901,0.00002440118,0.000006331843,0.0001820955,0.9951994,0.00007739894,0.00004576343,0.004114836],"study_design_scores_gemma":[0.00004051,0.001002705,0.000756355,0.00001397122,0.00003288992,0.000250446,0.000007377905,0.001057612,0.9894565,0.00007108926,0.00730575,0.000004877628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9396994,0.01431633,0.04068264,0.000491458,0.0003577587,0.0003746373,0.000619446,0.0003543298,0.003104005],"genre_scores_gemma":[0.967819,0.005655753,0.02252484,0.0002329977,0.00007610826,0.0001811952,0.0007833753,0.00003128908,0.002695316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007149871,"threshold_uncertainty_score":0.002391875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054325611110425,"score_gpt":0.2901356119299144,"score_spread":0.2695923558188101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}