{"id":"W2067931073","doi":"10.1016/j.ymthe.2005.10.018","title":"Development of Cell-Based Tuberculosis Vaccines: Genetically Modified Dendritic Cell Vaccine Is a Much More Potent Activator of CD4 and CD8 T Cells Than Peptide- or Protein-Loaded Counterparts","year":2005,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"McMaster University","keywords":"Virology; Genetically modified organism; Biology; Cytotoxic T cell; Tuberculosis vaccines; CD8; Antigen; Peptide vaccine; T cell; Tuberculosis; Immunology; Epitope; Immune system; Gene; Mycobacterium tuberculosis; Medicine; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000416243,0.0004202152,0.0009204897,0.0002694972,0.00007694466,0.00001507671,0.0002426732,0.0002453743,0.000274614],"category_scores_gemma":[0.00006680639,0.0003150076,0.0002199073,0.0002794784,0.00009139864,0.00005276346,0.00007333275,0.0002813149,0.00001503178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108051,"about_ca_system_score_gemma":0.0004273813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007271216,"about_ca_topic_score_gemma":0.00001522123,"domain_scores_codex":[0.9969966,0.0002077812,0.0009153636,0.0006065737,0.0006120914,0.0006616254],"domain_scores_gemma":[0.9982886,0.0001219884,0.0002227603,0.0006352661,0.0003161443,0.0004152434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00262688,0.001119073,0.0007541717,0.0004667434,0.0002707042,0.00005789182,0.0007657737,0.0001052273,0.9897887,0.000006083597,0.0003676059,0.003671204],"study_design_scores_gemma":[0.006139521,0.001007734,0.003970558,0.0001893837,0.00007392386,0.00001786882,0.0001599735,0.002297629,0.9843464,0.00001489285,0.001491342,0.0002907933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896947,0.001462578,0.003416932,0.003594578,0.000024451,0.001582899,0.00002262498,0.00003392437,0.0001672945],"genre_scores_gemma":[0.975534,0.0003634999,0.0211424,0.00241283,0.00004493426,0.0001849638,0.00003277009,0.00007192486,0.0002126464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01772547,"threshold_uncertainty_score":0.9999302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054325611110425,"score_gpt":0.2901356119299144,"score_spread":0.2695923558188101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}