{"id":"W2067933131","doi":"10.1007/s00401-008-0439-2","title":"Enduring involvement of tau, β-amyloid, α-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism–dementia complex of Guam (ALS/PDC)","year":2008,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; Progressive supranuclear palsy; Corticobasal degeneration; Pathology; Tauopathy; Parkinsonism; Autopsy; Dementia; Neuropathology; Medicine; Tangle; Disease; Degenerative disease; Neurofibrillary tangle; Tau protein; Lewy body; Dementia with Lewy bodies; Neuroscience; Neurodegeneration; Alzheimer's disease; Senile plaques; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000383508,0.0005720687,0.0003738583,0.002078531,0.0007598219,0.0008613914,0.000326772,0.0006439046,0.001652468],"category_scores_gemma":[0.001108152,0.0004050651,0.000227136,0.0005769565,0.000820733,0.0008495285,0.0006425422,0.0005242092,0.0002977832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003170907,"about_ca_system_score_gemma":0.0002926605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00147895,"about_ca_topic_score_gemma":0.002180325,"domain_scores_codex":[0.9998049,0.00002606684,0.0000315658,0.0000370399,0.00004714778,0.00005324705],"domain_scores_gemma":[0.9992214,0.0001367992,0.0002576953,0.00005865117,0.0001173861,0.0002081587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005065908,0.0003867892,0.5400985,0.000290151,0.0002638249,0.2352868,0.001424746,0.0003402671,0.1785963,0.001020274,0.0007806959,0.03644574],"study_design_scores_gemma":[0.0000472153,0.00061948,0.7514889,0.00003503287,0.0001636223,0.2337419,0.000327885,0.0004879668,0.01135577,0.0006790246,0.001023535,0.00002960584],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969663,0.0009627821,0.0001493468,0.00006180818,0.00001074104,0.000006601095,0.00004745071,0.00002214934,0.001772906],"genre_scores_gemma":[0.9993021,0.0001748707,0.0001369173,0.00002134526,0.00001205576,0.000002152555,0.00003902671,0.000004123109,0.0003072863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002078531,"threshold_uncertainty_score":0.005528092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102190680564473,"score_gpt":0.2816539260820801,"score_spread":0.1794632455176071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}