{"id":"W2067933131","doi":"10.1007/s00401-008-0439-2","title":"Enduring involvement of tau, β-amyloid, α-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism–dementia complex of Guam (ALS/PDC)","year":2008,"lang":"en","type":"article","venue":"Acta Neuropathologica","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Amyotrophic lateral sclerosis; Progressive supranuclear palsy; Corticobasal degeneration; Pathology; Tauopathy; Parkinsonism; Autopsy; Dementia; Neuropathology; Medicine; Tangle; Disease; Degenerative disease; Neurofibrillary tangle; Tau protein; Lewy body; Dementia with Lewy bodies; Neuroscience; Neurodegeneration; Alzheimer's disease; Senile plaques; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009777967,0.0003577944,0.0008476832,0.0002869778,0.0001976259,0.00002192575,0.0005572582,0.0001914917,0.0002567882],"category_scores_gemma":[0.0002836449,0.0002443059,0.0001643706,0.0004814922,0.001043431,0.0001377604,0.0005581741,0.0006567402,0.0000119712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004532595,"about_ca_system_score_gemma":0.00006088616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001060078,"about_ca_topic_score_gemma":0.00001140717,"domain_scores_codex":[0.9959508,0.0009431678,0.0009734261,0.0006826953,0.0007262968,0.0007236705],"domain_scores_gemma":[0.9982983,0.0002369016,0.0003659897,0.0007942557,0.0001570804,0.0001474294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00031701,0.0005605112,0.09471454,0.0001325125,0.0000330924,0.00168226,0.001499705,0.000009296722,0.8998374,0.0001204672,0.0003140197,0.0007791438],"study_design_scores_gemma":[0.002187319,0.001738548,0.9804744,0.0001301908,0.00006456041,0.0008613215,0.0001200211,0.00009664585,0.01345494,0.0001035524,0.0005684902,0.0002000186],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957594,0.0003717897,0.000007975273,0.002318558,0.00007040233,0.0008426288,0.00003085018,0.00004729103,0.000551127],"genre_scores_gemma":[0.9950543,0.002526898,0.0006686093,0.001482344,0.00008238482,0.00007091978,0.00002599756,0.000043128,0.00004542663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8863825,"threshold_uncertainty_score":0.9962505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.102190680564473,"score_gpt":0.2816539260820801,"score_spread":0.1794632455176071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}