{"id":"W2067992137","doi":"10.1016/j.chembiol.2007.07.011","title":"Deconvolution of the Cellular Oxidative Stress Response with Organelle-Specific Peptide Conjugates","year":2007,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Camille and Henry Dreyfus Foundation; National Science Foundation","keywords":"Oxidative stress; Organelle; Mitochondrion; Reactive oxygen species; Biology; Oxidative phosphorylation; Cell biology; Cell; Subcellular localization; Function (biology); Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004271912,0.0002339556,0.0002286609,0.00002080224,0.0001256779,0.000005339514,0.0004163301,0.0003962002,0.00009965556],"category_scores_gemma":[0.0002018194,0.0001555118,0.00009715203,0.000144403,0.001137361,0.00000343731,0.0001615615,0.0001934287,0.000006153623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002328685,"about_ca_system_score_gemma":0.00009743535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000585381,"about_ca_topic_score_gemma":0.00001472347,"domain_scores_codex":[0.9986356,0.000159284,0.0003031357,0.0004729689,0.00007042683,0.0003585267],"domain_scores_gemma":[0.9987763,0.0001347611,0.0002540405,0.000567809,0.000193132,0.00007401221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002364168,0.00006166912,0.04901344,0.00001928126,0.00008250221,0.000004173203,0.00006060404,0.000006477573,0.947932,0.00004352314,0.0002550879,0.0001570876],"study_design_scores_gemma":[0.0005902852,0.0002391354,0.0203038,0.00002553038,0.00001613591,0.00002147526,0.0004474573,0.000001105992,0.9654052,0.00004878653,0.01270729,0.0001938421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961082,0.001116806,0.0012814,0.0000965424,0.0001047712,0.0001636203,0.00009871215,0.00001218059,0.00101782],"genre_scores_gemma":[0.9981811,0.0001055992,0.0001894914,0.00006400295,0.0001721318,0.000008830743,0.0002810723,0.00001795198,0.0009798366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02870965,"threshold_uncertainty_score":0.6341586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006577569771727098,"score_gpt":0.2276130563520446,"score_spread":0.2210354865803175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}