{"id":"W2068067925","doi":"10.4161/chan.23981","title":"A uniquely adaptable pore is consistent with NALCN being an ion sensor","year":2013,"lang":"en","type":"article","venue":"Channels","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Centre National de la Recherche Scientifique; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Gating; Ion channel; Biophysics; Sodium channel; HEK 293 cells; Chemistry; Transmembrane protein; Calcium; Conductance; Coupling (piping); Sodium; Biochemistry; Materials science; Biology; Gene; Receptor; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001624087,0.0001601126,0.0002320893,0.0001962534,0.0002988395,0.0004944649,0.0005782609,0.0006998575,0.001244399],"category_scores_gemma":[0.0004577462,0.0001134209,0.0003529083,0.0001624843,0.0007207656,0.001397817,0.0006099761,0.0006224239,0.0004585876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002795708,"about_ca_system_score_gemma":0.0001742495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002685317,"about_ca_topic_score_gemma":0.0003877908,"domain_scores_codex":[0.9997981,0.00001190781,0.00001370892,0.00007970627,0.0000599198,0.00003660177],"domain_scores_gemma":[0.999631,0.00006441373,0.0000772813,0.00008762447,0.00007369466,0.00006592705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115152,0.00001224354,0.001758801,0.0000993367,0.000006657359,0.0007354837,0.00007483832,0.0001463177,0.9927204,0.001812805,0.0001223773,0.0023956],"study_design_scores_gemma":[0.00002279071,0.0001920189,0.02894283,0.00002614972,0.00005387819,0.01114969,0.0004422735,0.005360655,0.9350122,0.003531346,0.01522063,0.00004564505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.954895,0.0009143341,0.03522786,0.0006425412,0.00009089313,0.00005542146,0.0006647166,0.0005714647,0.006937878],"genre_scores_gemma":[0.9866477,0.0002466265,0.01053319,0.0002243806,0.00001376915,0.0000253495,0.0004483675,0.00003092561,0.001829608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244399,"threshold_uncertainty_score":0.004162908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801198463014464,"score_gpt":0.2292543007446494,"score_spread":0.2112423161145047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}