{"id":"W2068129834","doi":"10.1093/molehr/gat046","title":"Meeting the methodological challenges in molecular mapping of the embryonic epigenome","year":2013,"lang":"en","type":"review","venue":"Molecular Human Reproduction","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; McGill University; Montreal Children's Hospital","funders":"","keywords":"Epigenome; Biology; Reprogramming; Epigenetics; DNA methylation; Epigenomics; Genetics; Chromatin; Embryonic stem cell; Reproductive technology; Epigenesis; Computational biology; Gene; Gene expression; Embryogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04883799,0.0009800213,0.0015484,0.003148392,0.00150296,0.004263337,0.003590582,0.002560148,0.004242709],"category_scores_gemma":[0.05086395,0.001016757,0.001319433,0.002055146,0.005451951,0.003858003,0.005553431,0.00735293,0.003126762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001087967,"about_ca_system_score_gemma":0.00294553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001294658,"about_ca_topic_score_gemma":0.002753068,"domain_scores_codex":[0.9765368,0.0156011,0.001205703,0.002604208,0.003660263,0.0003920492],"domain_scores_gemma":[0.9443021,0.03629243,0.002316796,0.009562449,0.006771273,0.0007548837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000552058,0.0001729892,0.01448434,0.01210721,0.00109422,0.00125952,0.004249288,0.003114582,0.3796869,0.1590706,0.01825154,0.4059567],"study_design_scores_gemma":[0.0001274037,0.001217989,0.02813837,0.003491129,0.001072756,0.00647842,0.004233262,0.009756183,0.1446544,0.2502765,0.5501552,0.0003982901],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"review","genre_scores_codex":[0.008571459,0.05760509,0.9117874,0.01094366,0.00261611,0.0004761542,0.0007246235,0.0007193414,0.006556128],"genre_scores_gemma":[0.06724123,0.04128072,0.8739114,0.006025001,0.002027508,0.003206379,0.00112338,0.0009952815,0.004189215],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.04883799,"threshold_uncertainty_score":0.2582831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2024921299809918,"score_gpt":0.3708688115611273,"score_spread":0.1683766815801355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}