{"id":"W2068162750","doi":"10.1074/jbc.m100158200","title":"CD44-initiated Cell Spreading Induces Pyk2 Phosphorylation, Is Mediated by Src Family Kinases, and Is Negatively Regulated by CD45","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Medical Research Council Canada","keywords":"FYN; Tyrosine-protein kinase CSK; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Src family kinase; Protein tyrosine phosphatase; Tyrosine phosphorylation; Phosphorylation; Tyrosine kinase; Kinase; CD44; Biology; Cancer research; Chemistry; Signal transduction; SH2 domain; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005639291,0.0003779669,0.0001595037,0.0001704957,0.0001438268,0.000211701,0.00007776009,0.0001828702,0.001763933],"category_scores_gemma":[0.00008414756,0.0001192015,0.0002656973,0.0001423238,0.0001324773,0.0001353042,0.0002145119,0.0004322526,0.0004496387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148343,"about_ca_system_score_gemma":0.0001874865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006685583,"about_ca_topic_score_gemma":0.0008438577,"domain_scores_codex":[0.9998714,0.00001569375,0.000007658273,0.00002239441,0.0000310163,0.00005194808],"domain_scores_gemma":[0.9999273,0.000009266207,0.0000156212,0.000009142588,0.00001047416,0.00002814523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005980651,0.00001471537,0.0001211283,0.00001722109,0.000002718322,0.00003665279,0.000005561461,0.00001290238,0.9990656,0.00003560335,0.00002587401,0.0006023056],"study_design_scores_gemma":[0.00001641053,0.0001863525,0.012357,0.000004017333,0.000009698818,0.0003387804,0.0000155923,0.001321502,0.9847877,0.00004085603,0.0009188951,0.000003147514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952765,0.001117968,0.001448379,0.00004955796,0.00002346236,0.00002069586,0.0001493025,0.00003983139,0.001874196],"genre_scores_gemma":[0.9957641,0.0006390036,0.0009376724,0.00003472812,0.00001048791,0.00002401536,0.0003998508,0.000008492981,0.002181513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763933,"threshold_uncertainty_score":0.005900979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02707674283272894,"score_gpt":0.270128821982401,"score_spread":0.243052079149672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}