{"id":"W2068166817","doi":"10.1007/s10555-013-9451-7","title":"Biological insights into effective and antagonistic combinations of targeted agents with chemotherapy in solid tumors","year":2013,"lang":"en","type":"review","venue":"Cancer and Metastasis Reviews","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Regional Municipality of Durham","funders":"","keywords":"Drug; Pharmacology; Medicine; Identification (biology); Antagonism; Computational biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004516708,0.0007947293,0.001376683,0.001487393,0.0001824564,0.0007123713,0.0007542821,0.0005572086,0.003131424],"category_scores_gemma":[0.0004213238,0.0003050056,0.0005158979,0.001344213,0.0003442404,0.0007742104,0.0004287362,0.001483734,0.001267798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004045048,"about_ca_system_score_gemma":0.0005429925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005924897,"about_ca_topic_score_gemma":0.00148141,"domain_scores_codex":[0.9998531,0.00002533126,0.00001863106,0.00002342003,0.00006017686,0.0000193166],"domain_scores_gemma":[0.9998692,0.00006153432,0.0000230274,0.000005306415,0.00003088362,0.00001004351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002231383,0.0002082329,0.0001637809,0.01453398,0.0001472525,0.0001888599,0.00005301405,0.0008396021,0.0136403,0.003649929,0.01692795,0.949424],"study_design_scores_gemma":[0.0001304825,0.0005250733,0.00138522,0.002177388,0.0003802786,0.001491442,0.00004590245,0.0003376348,0.005653237,0.00221749,0.9856226,0.00003312472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004575595,0.9974523,0.0004202008,0.0001588126,0.0001203841,0.00001351878,0.00003573957,0.00001128824,0.001330114],"genre_scores_gemma":[0.002256795,0.9963084,0.0004645716,0.0001509397,0.0001072165,0.00001377719,0.00004844799,0.000002127404,0.0006477042],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003131424,"threshold_uncertainty_score":0.01047564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0806551080847331,"score_gpt":0.4255743826179348,"score_spread":0.3449192745332018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}