{"id":"W2068169802","doi":"10.1021/np2006555","title":"One-Pot Syntheses of Pseudopteroxazoles from Pseudopterosins: A Rapid Route to Non-natural Congeners with Improved Antimicrobial Activity","year":2011,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Natural product; Antimicrobial; Enterococcus faecium; Benzoxazole; Staphylococcus aureus; Microbiology; Catechol; Chemistry; Biology; Antibacterial agent; Combinatorial chemistry; Bacteria; Stereochemistry; Antibiotics; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004685623,0.0004872066,0.001280544,0.0004146201,0.00009907856,0.0000535328,0.0004840444,0.0001836277,0.00006565567],"category_scores_gemma":[0.000893881,0.0003164301,0.0002925716,0.0005844015,0.0002652486,0.0006593333,0.0001353875,0.0009749368,0.000009763948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001410142,"about_ca_system_score_gemma":0.0003493399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003277347,"about_ca_topic_score_gemma":0.00004643765,"domain_scores_codex":[0.9973177,0.0001090543,0.0008611822,0.0006258513,0.0005508998,0.0005353175],"domain_scores_gemma":[0.9964507,0.0001051439,0.001065856,0.0006234617,0.001491063,0.000263809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01005945,0.0005593528,0.0005523536,0.000184513,0.0007682988,0.00007136256,0.0006413576,0.000001157965,0.9554483,0.000002493142,0.001516122,0.03019518],"study_design_scores_gemma":[0.001560654,0.001405809,0.03936297,0.00121779,0.0005965382,0.0003619615,0.00006060639,0.00001886652,0.9546485,0.000005508939,0.0003616767,0.0003991467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919004,0.001184789,0.00001915256,0.004387584,0.001475198,0.0007914475,0.00006010989,0.00003117275,0.0001501295],"genre_scores_gemma":[0.9730486,0.0001935409,0.02468447,0.0006132861,0.001189417,9.048849e-7,0.000008276239,0.00005504887,0.0002064971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03881061,"threshold_uncertainty_score":0.9999288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920597036208051,"score_gpt":0.2328742376132489,"score_spread":0.2036682672511684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}