{"id":"W2068169802","doi":"10.1021/np2006555","title":"One-Pot Syntheses of Pseudopteroxazoles from Pseudopterosins: A Rapid Route to Non-natural Congeners with Improved Antimicrobial Activity","year":2011,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Agriculture and Agri-Food Canada; Natural Sciences and Engineering Research Council of Canada","keywords":"Natural product; Antimicrobial; Enterococcus faecium; Benzoxazole; Staphylococcus aureus; Microbiology; Catechol; Chemistry; Biology; Antibacterial agent; Combinatorial chemistry; Bacteria; Stereochemistry; Antibiotics; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002305133,0.0005447402,0.000310894,0.0001666199,0.0001899942,0.0001812243,0.0003610902,0.0003724827,0.001461832],"category_scores_gemma":[0.0002311256,0.0001971969,0.0003079068,0.0002059512,0.0002203165,0.0004746712,0.0003601761,0.0006729708,0.0006202837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661181,"about_ca_system_score_gemma":0.0003966383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000212579,"about_ca_topic_score_gemma":0.0008580895,"domain_scores_codex":[0.9998693,0.00002131353,0.00001850016,0.00002712818,0.00003946009,0.00002425508],"domain_scores_gemma":[0.9998833,0.00002002193,0.00004278227,0.00001539118,0.00001911163,0.00001943804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009713572,0.0000928522,0.0001413384,0.0004595803,0.0000253522,0.0002802929,0.0001361708,0.0005975608,0.982636,0.0009232449,0.0002896618,0.01432086],"study_design_scores_gemma":[0.00005919169,0.000751939,0.0007916193,0.00001488362,0.00002001292,0.0006665839,0.00005039551,0.0005984681,0.9890564,0.0002717246,0.007694511,0.00002421993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8603556,0.01150947,0.1111008,0.0005940212,0.0002528846,0.0006517526,0.001386747,0.0003848035,0.01376385],"genre_scores_gemma":[0.9516407,0.005449332,0.03698087,0.00009405419,0.00002416071,0.0001927702,0.0003709617,0.00004439463,0.00520274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461832,"threshold_uncertainty_score":0.004890323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920597036208051,"score_gpt":0.2328742376132489,"score_spread":0.2036682672511684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}