{"id":"W2068172466","doi":"10.1039/c4bm00224e","title":"The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers","year":2014,"lang":"en","type":"article","venue":"Biomaterials Science","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"National Health and Medical Research Council; University of New South Wales; Analytical Center for the Government of the Russian Federation","keywords":"Endocytosis; Endocytic cycle; Chemistry; Confocal microscopy; Internalization; Doxorubicin; Cytotoxicity; Flow cytometry; Drug delivery; Clathrin; Fluorescence microscope; Pinocytosis; Biophysics; Drug carrier; Cancer cell; Molecular biology; Cell; Cell biology; Biochemistry; Fluorescence; In vitro; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001423327,0.000250648,0.0001639514,0.0001294686,0.00005855105,0.0001599128,0.0001088611,0.0001957079,0.0006056504],"category_scores_gemma":[0.0001984289,0.00008275505,0.0001311369,0.0001200048,0.00009918583,0.0002060555,0.00008765224,0.0002314798,0.0001495455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002703577,"about_ca_system_score_gemma":0.0001473844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005067053,"about_ca_topic_score_gemma":0.0003948339,"domain_scores_codex":[0.9999043,0.00002506628,0.000008044916,0.0000199833,0.00002157856,0.00002113756],"domain_scores_gemma":[0.9998857,0.00004507774,0.00002951436,0.000008277014,0.00001710612,0.00001421692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001449578,0.00002440516,0.0001390451,0.0000398031,0.00000397618,0.00003208463,0.00001163635,0.0001388936,0.9972908,0.00007449961,0.00001914057,0.002080882],"study_design_scores_gemma":[0.000006673601,0.0003333186,0.001340533,0.000003141761,0.00001194835,0.00007630819,0.000005485473,0.001368082,0.9962229,0.00001498133,0.000613553,0.000003086794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953903,0.00207428,0.001419604,0.00004257484,0.00001413144,0.00001658803,0.000102657,0.00002558632,0.0009143054],"genre_scores_gemma":[0.9964249,0.001026032,0.001338573,0.00001700455,0.000005982141,0.00002168249,0.0001092006,0.000009481071,0.001047345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006056504,"threshold_uncertainty_score":0.002026081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130847712396127,"score_gpt":0.2325952827737865,"score_spread":0.2212868056498252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}