{"id":"W2068257329","doi":"10.1016/j.ejmech.2011.01.026","title":"Identification, structural properties and chelating capacity of miltipolone as a broad-spectrum inhibitor to cancer cells","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Traditional Chinese Medicine Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Nanjing Agricultural University; Nanjing University; Chinese Academy of Sciences; Heart and Stroke Foundation of Canada","keywords":"Chemistry; Chelation; Hydrogen bond; Intermolecular force; Broad spectrum; Absorption (acoustics); Absorption spectroscopy; Cancer cell; Lead compound; Crystal structure; Cancer; Crystallography; Stereochemistry; Molecule; Combinatorial chemistry; In vitro; Biochemistry; Inorganic chemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001449742,0.0002166085,0.0002276514,0.0002697825,0.0001970458,0.0002147446,0.0002594745,0.0002393235,0.001665247],"category_scores_gemma":[0.0002188766,0.0001094626,0.0002394803,0.0002555138,0.0001535463,0.0001710505,0.0001206493,0.0002486657,0.0004403199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001878048,"about_ca_system_score_gemma":0.0002214288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001640076,"about_ca_topic_score_gemma":0.001290098,"domain_scores_codex":[0.9999276,0.00001495427,0.000007352523,0.00001083162,0.00001752804,0.00002161258],"domain_scores_gemma":[0.9999063,0.00002262633,0.00001497344,0.00001373951,0.00002353839,0.00001888018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002852152,0.00002276042,0.0003371477,0.00004110538,0.00000554141,0.00004349633,0.00001922815,0.00009453719,0.9972367,0.00003430028,0.00005316617,0.001826751],"study_design_scores_gemma":[0.00002938448,0.0005746483,0.00420197,0.000003187394,0.00002967217,0.0002626354,0.00001975413,0.0004342904,0.9921286,0.000018016,0.002292389,0.000005450475],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909005,0.004211642,0.002077065,0.0001622443,0.00001593547,0.00005505138,0.0006688198,0.00007427349,0.001834379],"genre_scores_gemma":[0.9950958,0.001206821,0.001123473,0.00004636902,0.00001002837,0.00002195443,0.00114212,0.00001127881,0.001342072],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001665247,"threshold_uncertainty_score":0.005570769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04193406905187536,"score_gpt":0.2468898538345688,"score_spread":0.2049557847826934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}