{"id":"W2068259251","doi":"10.1074/jbc.m114.613984","title":"The Fab1/PIKfyve Phosphoinositide Phosphate Kinase Is Not Necessary to Maintain the pH of Lysosomes and of the Yeast Vacuole","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Toronto Metropolitan University","funders":"Hospital for Sick Children; Government of Ontario; University of California, San Francisco; University of Toronto; Natural Sciences and Engineering Research Council of Canada; Johns Hopkins University","keywords":"Vacuole; Lysosome; Cell biology; Yeast; Biology; Biochemistry; Organelle; Saccharomyces cerevisiae; Cytoplasm; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000520276,0.0001232902,0.0001946426,0.000006274653,0.00007177885,0.00001367805,0.0003979635,0.0001419109,0.00001703237],"category_scores_gemma":[0.0001435273,0.00005430202,0.0001846071,0.00007929733,0.0002436853,0.000003534609,0.0001180192,0.0001671122,4.764851e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001176441,"about_ca_system_score_gemma":0.00007459633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001180574,"about_ca_topic_score_gemma":0.000002718549,"domain_scores_codex":[0.9990928,0.00004877273,0.0003778412,0.0001339249,0.0001932544,0.0001534203],"domain_scores_gemma":[0.999114,0.00003633418,0.0003153184,0.0002475549,0.0001793547,0.0001073725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004562123,0.00004038762,0.009609008,0.00001503868,0.00005292269,0.000004310699,0.00008291232,0.00001460683,0.9883294,0.00001978783,0.000476064,0.0008994143],"study_design_scores_gemma":[0.0004109725,0.0001937105,0.008596838,0.00002867858,0.00003070327,0.00004477541,0.0004693806,0.000008739212,0.9782514,0.0002797246,0.01160832,0.00007678666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949406,0.002872495,0.0002478654,0.001533355,0.00007718988,0.00008397045,0.00003638731,0.00000138304,0.0002067737],"genre_scores_gemma":[0.9987357,0.0005422516,0.00005442109,0.0003412308,0.0001372688,0.000002195511,0.00001867959,0.000006138231,0.0001620712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01113226,"threshold_uncertainty_score":0.2214372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589029558813163,"score_gpt":0.2317286155407895,"score_spread":0.2158383199526579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}