{"id":"W2068276081","doi":"10.1097/00002030-200305230-00020","title":"Prolonged retention of drug resistance mutations and rapid disease progression in the absence of therapy after primary HIV infection","year":2003,"lang":"en","type":"letter","venue":"AIDS","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Providence Health Care","funders":"","keywords":"Reverse transcriptase; Drug resistance; Discontinuation; Virology; Lentivirus; Protease; Sida; Viral disease; Medicine; Drug; Human immunodeficiency virus (HIV); Mutation; Protease inhibitor (pharmacology); HIV drug resistance; Immunology; Antiretroviral therapy; Biology; Viral load; Internal medicine; Enzyme; Pharmacology; Genetics; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002790147,0.0001662299,0.0002782555,0.0001878361,0.00003452196,0.000008221345,0.00004364684,0.0001213823,0.00002919904],"category_scores_gemma":[0.000034265,0.0001042211,0.00007952415,0.0002450475,0.0001217264,0.00006879422,0.00001058031,0.0003013525,0.000002110513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005050973,"about_ca_system_score_gemma":0.0001191246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000402492,"about_ca_topic_score_gemma":0.000004264364,"domain_scores_codex":[0.9987548,0.0002074927,0.0003201359,0.0002360807,0.0003515806,0.0001299186],"domain_scores_gemma":[0.9993545,0.00007875354,0.0001985186,0.0002602231,0.00008174992,0.00002628114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001364763,0.0006294915,0.7362704,0.002133769,0.0002277758,0.0003812639,0.003408814,2.635051e-7,0.0002748677,0.0000245418,0.2414401,0.01384388],"study_design_scores_gemma":[0.003045951,0.0001784804,0.8646961,0.002176529,0.0002608615,0.0000100132,0.00005357727,0.000004132901,0.0006212621,0.0003665062,0.1283504,0.0002361519],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8177257,0.005597206,0.00003433828,0.1732276,0.0001066316,0.002358379,0.00003077549,0.00002370907,0.0008956466],"genre_scores_gemma":[0.9205621,0.003661618,0.003562139,0.04444786,0.0002794745,0.001644244,0.001765942,0.00007245883,0.02400412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1287797,"threshold_uncertainty_score":0.4250014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111345286796638,"score_gpt":0.2527924710056558,"score_spread":0.241657942325992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}