{"id":"W2068328991","doi":"10.1038/nrmicro2875","title":"Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs","year":2012,"lang":"en","type":"review","venue":"Nature Reviews Microbiology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; European Commission; Wellcome Trust","keywords":"Hsp90; Biology; Interactome; Cell biology; Heat shock protein; Transcription factor; HSF1; Kinase; Heat shock; Computational biology; Genetics; Hsp70; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.002007995,0.001250968,0.003564872,0.0003384682,0.0002413744,0.0000353404,0.001799283,0.004242108,0.0001873388],"category_scores_gemma":[0.0002287485,0.0008657732,0.001737466,0.0004917536,0.0002426646,0.000005489762,0.001094385,0.002999416,0.0009818644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001965493,"about_ca_system_score_gemma":0.0004554222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005408006,"about_ca_topic_score_gemma":0.00001376041,"domain_scores_codex":[0.9919438,0.00344746,0.001190671,0.001702031,0.0001791533,0.001536926],"domain_scores_gemma":[0.9973213,0.00008028628,0.0004378238,0.001541942,0.0001377663,0.000480854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006834529,0.0001930877,0.00001400867,0.005950464,0.0003139755,0.00003952439,0.00002986688,1.638824e-7,0.261129,0.00002511615,0.007118884,0.7251176],"study_design_scores_gemma":[0.0002052353,0.0004551224,0.000001846308,0.001295274,0.0002911417,0.0005487278,0.000001913112,2.486773e-8,0.006731678,0.000001005573,0.9895393,0.000928735],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002814765,0.992671,0.0002623499,0.0001655939,0.000959085,0.004714564,0.0006497837,0.00003984215,0.0002563785],"genre_scores_gemma":[0.0009797539,0.9895849,0.0007370856,0.001192199,0.001730055,0.001344391,0.002973326,0.0001613559,0.001296975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9824204,"threshold_uncertainty_score":0.999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07411868740140612,"score_gpt":0.3509400345809736,"score_spread":0.2768213471795675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}