{"id":"W2068374687","doi":"10.1016/s0042-6822(03)00073-4","title":"Mapping of determinants required for the function of the HIV-1 env nuclear retention sequence","year":2003,"lang":"en","type":"article","venue":"Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; University of Toronto","funders":"Ontario HIV Treatment Network","keywords":"Biology; RNA; Intron; Nuclear export signal; Mutagenesis; RNA-binding protein; Molecular biology; Sequence analysis; Electrophoretic mobility shift assay; Cytoplasm; Nuclear transport; Heterogeneous ribonucleoprotein particle; Sequence (biology); Viral replication; Cell nucleus; Cell biology; Genetics; Mutation; Virus; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799113,0.0002974447,0.0002352587,0.0002211841,0.0003213425,0.0005353097,0.000285974,0.0003093168,0.001654146],"category_scores_gemma":[0.0003682245,0.0002184417,0.0002686903,0.0001391179,0.0004431561,0.0002994921,0.0002645676,0.0008346225,0.0008313511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005023303,"about_ca_system_score_gemma":0.0004792794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00209568,"about_ca_topic_score_gemma":0.001834916,"domain_scores_codex":[0.9998924,0.00002610988,0.000008568128,0.00001611801,0.00002269136,0.00003412379],"domain_scores_gemma":[0.9995266,0.0002076521,0.00009120497,0.00005407974,0.00004441975,0.00007605649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001602079,0.00003050209,0.0001966536,0.00001527902,0.000002035491,0.00006892112,0.00002635432,0.0001431703,0.9980739,0.0003425886,0.00001943943,0.0009207603],"study_design_scores_gemma":[0.00003053921,0.0002547917,0.01074532,0.00001238128,0.00001895639,0.0006348894,0.00012265,0.001866018,0.9842021,0.0002326849,0.001865705,0.0000139172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949604,0.0003902916,0.00311464,0.00007280048,0.00001147805,0.00001914805,0.0001186115,0.00002984454,0.001282759],"genre_scores_gemma":[0.9971457,0.0001643913,0.001390344,0.00004023971,0.000006055747,0.000007932968,0.0002918788,0.00002834918,0.000925024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00209568,"threshold_uncertainty_score":0.005533695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04055817049778934,"score_gpt":0.2644531095093887,"score_spread":0.2238949390115994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}