{"id":"W2068380930","doi":"10.2353/ajpath.2007.070101","title":"Aldosterone Induces Elastin Production in Cardiac Fibroblasts through Activation of Insulin-Like Growth Factor-I Receptors in a Mineralocorticoid Receptor-Independent Manner","year":2007,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Heart and Stroke Foundation; Canadian Institutes of Health Research; SickKids Foundation; Toronto General Hospital; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Mineralocorticoid receptor; Aldosterone; Endocrinology; Internal medicine; Mineralocorticoid; Elastin; Tropoelastin; Spironolactone; Receptor; Insulin-like growth factor 1 receptor; Insulin-like growth factor; Chemistry; Biology; Growth factor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002887619,0.0004411072,0.0003074428,0.0003363405,0.0002712133,0.0003966466,0.0001424006,0.0002634713,0.001790513],"category_scores_gemma":[0.0002453178,0.0002497013,0.0005311678,0.0001800529,0.0002719759,0.0002551314,0.000296673,0.0009219438,0.0004946822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327971,"about_ca_system_score_gemma":0.0001762902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118266,"about_ca_topic_score_gemma":0.001883439,"domain_scores_codex":[0.999648,0.00007652302,0.00003946185,0.00004739873,0.00009035286,0.00009833428],"domain_scores_gemma":[0.9996706,0.0001245099,0.00003516463,0.00004489774,0.00003325817,0.00009157582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003079749,0.00005103579,0.0002129863,0.00003843301,0.00000648554,0.0001293051,0.00003112284,0.000014112,0.9983809,0.00005007092,0.00006158435,0.0007159043],"study_design_scores_gemma":[0.00009902759,0.0005785736,0.01714865,0.000008272309,0.00002730212,0.0004071775,0.0001319769,0.0003081711,0.9790639,0.00008741963,0.002128399,0.00001114349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896952,0.00274629,0.002191547,0.000324907,0.0002185877,0.00005281827,0.0005815274,0.00007156221,0.004117503],"genre_scores_gemma":[0.9930997,0.001100485,0.001556415,0.0001680438,0.00008652399,0.00006091736,0.0005140459,0.00001505253,0.003398804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790513,"threshold_uncertainty_score":0.005989909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191512367795738,"score_gpt":0.2746397642175154,"score_spread":0.2554885274379416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}