{"id":"W2068383144","doi":"10.1021/bi802251s","title":"Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Enzyme kinetics; Chemistry; Aroa; Aromatic amino acids; Active site; Tetrahedral carbonyl addition compound; Stereochemistry; Catalysis; Transition state; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002521398,0.000372735,0.0002858639,0.00004992133,0.0001712337,0.0001261316,0.0004084734,0.0003381534,0.00001892142],"category_scores_gemma":[0.0001471799,0.0003505998,0.0001208476,0.0001757171,0.0002152528,0.00001380472,0.0001618732,0.0002337171,0.00001124291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003433263,"about_ca_system_score_gemma":0.0001447707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004143656,"about_ca_topic_score_gemma":0.00001003756,"domain_scores_codex":[0.9977614,0.00004732648,0.0002626195,0.0009273139,0.0003292768,0.0006720448],"domain_scores_gemma":[0.99853,0.00001090483,0.0000982432,0.0008327967,0.0001010762,0.0004269246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833233,0.0001804942,0.0003179552,0.00008334711,0.00006887526,0.00003431369,0.00004129383,6.69034e-7,0.9912481,0.0000134204,0.001001634,0.006826548],"study_design_scores_gemma":[0.0005891792,0.0003919468,0.0005891116,0.0000373475,0.00006516894,0.00007903262,0.00005380642,0.00007226346,0.9962976,0.0001971615,0.001174126,0.0004532674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932238,0.004703754,0.0001543059,0.0005688313,0.00002328761,0.0002443405,0.00005207404,0.00005165225,0.0009779214],"genre_scores_gemma":[0.9959313,0.0005107688,0.0006892914,0.0003995051,0.0001743632,0.00002850844,0.001140392,0.00003922034,0.001086683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006373281,"threshold_uncertainty_score":0.9998946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013146813303763,"score_gpt":0.2799343308215462,"score_spread":0.2698028626885086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}