{"id":"W2068383144","doi":"10.1021/bi802251s","title":"Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Enzyme kinetics; Chemistry; Aroa; Aromatic amino acids; Active site; Tetrahedral carbonyl addition compound; Stereochemistry; Catalysis; Transition state; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914689,0.0003464172,0.0002629363,0.00007557433,0.0001816838,0.0004027831,0.0002300474,0.0003882313,0.0007145266],"category_scores_gemma":[0.0003263848,0.0001840325,0.0002770236,0.00008324569,0.0002346888,0.0003446215,0.0004533015,0.0004133339,0.0004207873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002059992,"about_ca_system_score_gemma":0.0001989648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001794284,"about_ca_topic_score_gemma":0.0001800847,"domain_scores_codex":[0.9998893,0.00002088182,0.00001162169,0.00002739673,0.00002923224,0.0000216075],"domain_scores_gemma":[0.9998727,0.00002156379,0.00003577307,0.000009220771,0.00001677913,0.00004400813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001633759,0.00003192769,0.0004808503,0.00003302832,0.00000831877,0.0001372112,0.00002231813,0.0003373005,0.9972882,0.0002985894,0.00003776084,0.001161133],"study_design_scores_gemma":[0.00006293412,0.000294778,0.006866575,0.00001259793,0.0000258371,0.0007932957,0.00009795035,0.004822134,0.9848296,0.0005008159,0.001671784,0.00002174026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951337,0.0004936191,0.003126153,0.00007903507,0.00002439563,0.00001742832,0.00003946212,0.00006837972,0.001017763],"genre_scores_gemma":[0.998024,0.0001139239,0.00148477,0.00003414406,0.000002877996,0.00000780701,0.0000352505,0.000009154151,0.0002881748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007145266,"threshold_uncertainty_score":0.002390385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013146813303763,"score_gpt":0.2799343308215462,"score_spread":0.2698028626885086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}