{"id":"W2068390438","doi":"10.1021/bi002209v","title":"Binding of Plasminogen and Tissue Plasminogen Activator to Plasmin-Modulated Factor X and Factor Xa","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"","keywords":"Plasmin; Chemistry; Benzamidine; Plasminogen activator; Tissue plasminogen activator; Binding site; Stereochemistry; Protein subunit; Activator (genetics); Surface plasmon resonance; T-plasminogen activator; Cleavage (geology); Lysine; Enzyme; Receptor; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004367807,0.0002286446,0.0003741182,0.00009885365,0.0000646363,0.00002139549,0.00007506787,0.0002341621,0.000324047],"category_scores_gemma":[0.00009485719,0.0002165065,0.00004077456,0.0001867998,0.00005878105,0.00005385744,0.00008644525,0.000117351,0.00001740548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004231593,"about_ca_system_score_gemma":0.0000588534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001397031,"about_ca_topic_score_gemma":0.000001591351,"domain_scores_codex":[0.9988275,0.00001123002,0.0002735782,0.0003930325,0.0002411198,0.0002535723],"domain_scores_gemma":[0.9991369,0.00005413477,0.0001046504,0.0002604857,0.00006662493,0.0003772195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241087,0.00007711999,0.0131239,0.0001308013,0.0000904472,0.00001350415,0.0002668249,2.684457e-7,0.9824278,0.00001146956,0.0001048228,0.003628889],"study_design_scores_gemma":[0.001126031,0.0001789162,0.02728471,0.000129422,0.00005770408,0.000109444,0.0001783911,0.00006101953,0.9693339,0.000009588863,0.001320819,0.0002100945],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985933,0.0001310264,0.00005945109,0.0002308767,0.00007860683,0.0002816192,0.0001064646,0.00006219846,0.0004565046],"genre_scores_gemma":[0.9976346,0.0000450909,0.000895231,0.0001030255,0.00008399042,0.000009499239,0.00003481041,0.00003075063,0.001163033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01416081,"threshold_uncertainty_score":0.8828881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862252682682723,"score_gpt":0.2830089387500433,"score_spread":0.254386411923216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}