{"id":"W2068420983","doi":"10.1038/aps.2014.57","title":"Alzheimer's disease progression model based on integrated biomarkers and clinical measures","year":2014,"lang":"en","type":"article","venue":"Acta Pharmacologica Sinica","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; Genentech; National Institutes of Health; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; Amorfix Life Sciences; Medpace; Biogen; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Dana Foundation; Synarc; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Dementia; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's disease; Internal medicine; Hippocampal formation; Medicine; Disease; Logistic regression; Cognition; Effects of sleep deprivation on cognitive performance; Cerebrospinal fluid; Cognitive decline; Psychology; Oncology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00324215,0.001680842,0.001500538,0.001969792,0.0006653757,0.002136114,0.001799593,0.001148434,0.003512601],"category_scores_gemma":[0.00327473,0.0004275188,0.001906477,0.0009114241,0.0004698002,0.001019424,0.0009419973,0.001838385,0.001269571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001332345,"about_ca_system_score_gemma":0.002496818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01987025,"about_ca_topic_score_gemma":0.01434536,"domain_scores_codex":[0.9992796,0.0002483571,0.00004420287,0.00021344,0.00009936232,0.0001151033],"domain_scores_gemma":[0.9987399,0.0004791793,0.0002003845,0.00007133016,0.0003650062,0.0001442025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004819694,0.001914843,0.3081183,0.0005702935,0.002640732,0.001221811,0.0009032423,0.4937063,0.00289367,0.02614705,0.01055407,0.14651],"study_design_scores_gemma":[0.000281786,0.001092816,0.03840929,0.0001129305,0.001309878,0.0007514557,0.0001977168,0.938569,0.0004257199,0.0160232,0.002752108,0.00007414847],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7720189,0.003932524,0.193578,0.004149881,0.0005219151,0.0008508505,0.008992289,0.001486918,0.01446869],"genre_scores_gemma":[0.9729884,0.0009064842,0.01594904,0.0001112618,0.00008459719,0.0004130797,0.002282013,0.00003928132,0.007225799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01987025,"threshold_uncertainty_score":0.03950918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07606917318254441,"score_gpt":0.4321867550973478,"score_spread":0.3561175819148034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}