{"id":"W2068470826","doi":"10.1073/pnas.1013822108","title":"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"NHLBI Division of Intramural Research; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Terry Fox Foundation","keywords":"Proteolysis; Crosstalk; Cell biology; Cleavage (geology); Biology; Protein subunit; Ubiquitin; Gene; Transcription factor; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006194697,0.00007278342,0.00007035063,0.00005519358,0.0002335705,0.00003236095,0.000359022,0.00009139195,0.00000935025],"category_scores_gemma":[0.0002216443,0.00004171885,0.00003778051,0.0002345584,0.0006067617,0.00003874195,0.0001353854,0.00009889412,9.293727e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007646269,"about_ca_system_score_gemma":0.00002883597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008710831,"about_ca_topic_score_gemma":1.914966e-7,"domain_scores_codex":[0.9989806,0.00001126747,0.0001951586,0.0001871445,0.0005139307,0.0001119162],"domain_scores_gemma":[0.9995093,0.00002223294,0.0002324448,0.00001321446,0.0001966303,0.00002621542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002557686,0.00001331067,0.01079536,0.00003024324,0.000005835343,1.59322e-9,0.0001963976,0.000001798632,0.9870812,0.001297504,0.000072627,0.0004801001],"study_design_scores_gemma":[0.00008493344,0.00005053063,0.3135546,0.00001072341,0.00000223838,0.000001211169,0.00006911492,0.00008940737,0.6835859,0.002334161,0.0001797081,0.00003752282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948015,0.0001032084,0.000004690696,0.0005200954,0.000006361343,0.0003417951,0.00001635352,0.000003645694,0.004202393],"genre_scores_gemma":[0.9991466,0.00002043364,0.0003824527,0.00004691749,0.00005875834,0.00001170067,7.799508e-7,0.000003748371,0.0003286457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3034954,"threshold_uncertainty_score":0.2235638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05074828544623989,"score_gpt":0.2917318363943834,"score_spread":0.2409835509481436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}