{"id":"W2068470826","doi":"10.1073/pnas.1013822108","title":"Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"NHLBI Division of Intramural Research; National Institutes of Health; Fonds Québécois de la Recherche sur la Nature et les Technologies; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Terry Fox Foundation","keywords":"Proteolysis; Crosstalk; Cell biology; Cleavage (geology); Biology; Protein subunit; Ubiquitin; Gene; Transcription factor; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039696,0.000323225,0.0002260401,0.0001687425,0.000204975,0.0005493878,0.0001473703,0.0002567395,0.0009546526],"category_scores_gemma":[0.0001091536,0.0001474879,0.0002072711,0.0001065743,0.000172755,0.0003224224,0.00034846,0.0005150889,0.0003715184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705195,"about_ca_system_score_gemma":0.0002708794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005021395,"about_ca_topic_score_gemma":0.0007014427,"domain_scores_codex":[0.9998418,0.00002175796,0.000006608634,0.0000396422,0.00002643557,0.00006372792],"domain_scores_gemma":[0.999905,0.000008592547,0.00002636101,0.00000501957,0.00001566549,0.0000394264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001411955,0.00001533482,0.0006553918,0.00002475512,0.00000459216,0.0000999375,0.00001615087,0.00006124148,0.9972512,0.0001463223,0.00007806185,0.001505746],"study_design_scores_gemma":[0.00003941644,0.0002788046,0.09994086,0.00002310434,0.00003443383,0.0008095302,0.000226838,0.004974512,0.8863053,0.0005039478,0.00684203,0.00002128804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883385,0.006180794,0.002506795,0.0001834886,0.00004602244,0.0000251899,0.0002488317,0.00007978734,0.002390537],"genre_scores_gemma":[0.9956347,0.001291562,0.000940303,0.0000646189,0.00001699154,0.00001768148,0.0002492617,0.00001282253,0.001772018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009546526,"threshold_uncertainty_score":0.003413856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05074828544623989,"score_gpt":0.2917318363943834,"score_spread":0.2409835509481436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}