{"id":"W2068519421","doi":"10.1210/en.2003-0453","title":"Endogenous Melanocortin Antagonist in Fish: Structure, Brain Mapping, and Regulation by Fasting of the Goldfish Agouti-Related Protein Gene","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"Melanocortin; Melanocortin 3 receptor; Internal medicine; Endocrinology; Arcuate nucleus; Biology; Melanocortin 4 receptor; Melanocortin receptor; Hypothalamus; In situ hybridization; Antagonist; Nucleus; Endogeny; Agonist; Receptor; Neuropeptide; Gene expression; Gene; Cell biology; Hormone; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004991081,0.0001608848,0.0001594582,0.0002855381,0.0002042497,0.0001654671,0.0001367972,0.0001461857,0.0008780663],"category_scores_gemma":[0.00007640104,0.0001938199,0.0001756833,0.0001141731,0.0002836147,0.0001806851,0.0002341224,0.0002450394,0.0001723959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004581157,"about_ca_system_score_gemma":0.0002613096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003059848,"about_ca_topic_score_gemma":0.005368541,"domain_scores_codex":[0.9999605,0.000002529293,0.000002539885,0.00001546672,0.000008597959,0.00001036252],"domain_scores_gemma":[0.9999576,0.000004437442,0.00001504165,0.000004693637,0.000006134378,0.00001222514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008429177,0.000005272155,0.0009346279,0.00003075909,0.000004602475,0.00008847216,0.00002453119,0.00002509962,0.9962774,0.0001481298,0.00002236075,0.002354406],"study_design_scores_gemma":[0.00008129828,0.0007494768,0.3173422,0.00003452726,0.00009345853,0.002761065,0.0003700274,0.001121735,0.6697155,0.0005893633,0.00711229,0.00002907853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949645,0.001580116,0.001296021,0.00008201753,0.0000105577,0.00001310031,0.0001377288,0.00002094724,0.001894982],"genre_scores_gemma":[0.9896746,0.001352314,0.003158859,0.00007170426,0.000007872375,0.00004947133,0.000368325,0.00002530052,0.005291431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003059848,"threshold_uncertainty_score":0.006084025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02151398116061139,"score_gpt":0.2262603434259655,"score_spread":0.2047463622653541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}