{"id":"W2068519421","doi":"10.1210/en.2003-0453","title":"Endogenous Melanocortin Antagonist in Fish: Structure, Brain Mapping, and Regulation by Fasting of the Goldfish Agouti-Related Protein Gene","year":2003,"lang":"en","type":"article","venue":"Endocrinology","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"Melanocortin; Melanocortin 3 receptor; Internal medicine; Endocrinology; Arcuate nucleus; Biology; Melanocortin 4 receptor; Melanocortin receptor; Hypothalamus; In situ hybridization; Antagonist; Nucleus; Endogeny; Agonist; Receptor; Neuropeptide; Gene expression; Gene; Cell biology; Hormone; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001021983,0.0001390088,0.0002015677,0.00009484207,0.0001720915,0.00001863134,0.00017729,0.00008926344,0.00007512598],"category_scores_gemma":[0.0005910104,0.0001165073,0.00003743184,0.0003274917,0.0002478096,0.00007922521,0.00007515872,0.0001981629,0.000002573464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003017134,"about_ca_system_score_gemma":0.00004033981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007130007,"about_ca_topic_score_gemma":0.0000667213,"domain_scores_codex":[0.9984064,0.0003566931,0.0003921279,0.0003582585,0.0001525262,0.0003339727],"domain_scores_gemma":[0.999307,0.0001165361,0.0002607095,0.0002597347,0.00002083804,0.0000351425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008955113,0.00002682909,0.0184968,0.00001207835,0.000003253066,0.00001030348,0.0001704638,0.00007180047,0.9726503,0.007414836,0.00009792938,0.001036417],"study_design_scores_gemma":[0.000636175,0.00003962157,0.09497494,0.00001539976,0.000003036731,0.0002027949,0.00002620071,0.0001330547,0.8973963,0.002436587,0.004026378,0.000109552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964532,0.00004961478,0.00006391949,0.0008092143,0.0001238418,0.0004895001,0.00002631236,0.00003126487,0.001953122],"genre_scores_gemma":[0.9986545,0.00001116344,0.0001372765,0.000252186,0.00001214661,0.000009739138,0.000006167547,0.00001268135,0.0009040916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07647814,"threshold_uncertainty_score":0.4751031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02151398116061139,"score_gpt":0.2262603434259655,"score_spread":0.2047463622653541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}