{"id":"W2068549807","doi":"10.2217/fon.14.208","title":"Dovitinib (CHIR258, TKI258): Structure, Development and Preclinical and Clinical Activity","year":2015,"lang":"en","type":"article","venue":"Future Oncology","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Medicine; Sorafenib; Platelet-derived growth factor receptor; Tyrosine-kinase inhibitor; Receptor; Pharmacology; VEGF receptors; Receptor tyrosine kinase; Cancer research; Tyrosine kinase; Oncology; Cancer; Internal medicine; Growth factor; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006696468,0.0001831283,0.0003149247,0.00004033979,0.00007124243,0.00002315541,0.0001969038,0.0006497463,0.00001896927],"category_scores_gemma":[0.0005508382,0.0001546711,0.00004435047,0.00005673539,0.000311708,0.000006242332,0.0006188701,0.0004150815,0.000009177131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003669244,"about_ca_system_score_gemma":0.0005541631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009806578,"about_ca_topic_score_gemma":0.000401957,"domain_scores_codex":[0.9982708,0.0003603731,0.0003072672,0.0005666674,0.0001645702,0.0003303899],"domain_scores_gemma":[0.9989755,0.0001043669,0.00009948989,0.0003081688,0.0000992645,0.0004132586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005068912,0.0007135253,0.3680168,0.0001328558,0.0005298816,0.00009496544,0.0004372992,0.000001632994,0.08371187,0.0004424597,0.04582447,0.4950253],"study_design_scores_gemma":[0.0027075,0.002312828,0.2000365,0.000008334062,0.00002069503,0.000145504,0.0001196063,0.0000247993,0.0162348,0.0001581407,0.7779499,0.000281498],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962174,0.0005052194,0.00006330344,0.001020845,0.0005362993,0.0002368026,0.00001949732,0.0000158053,0.001384862],"genre_scores_gemma":[0.9915535,0.0001247908,0.006217896,0.0003156878,0.00143509,0.00001166303,0.0000548726,0.00002385039,0.0002626451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7321253,"threshold_uncertainty_score":0.6307305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06228528774817588,"score_gpt":0.404677689405457,"score_spread":0.3423924016572811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}