{"id":"W2068558726","doi":"10.1182/blood.v99.6.2138","title":"A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28","year":2002,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Connaught Fund","keywords":"CD28; Gene isoform; Transmembrane domain; Molecular biology; Transmembrane protein; Biology; splice; Alternative splicing; Tyrosine kinase; Signal transduction; T cell; Jurkat cells; Exon; Cell biology; Receptor; Gene; Biochemistry; Immunology; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000932596,0.0002112802,0.0001472832,0.0000854734,0.0001139311,0.0002707756,0.0001670512,0.00018378,0.0007517439],"category_scores_gemma":[0.000126807,0.00007866223,0.000164023,0.00009034085,0.0001165139,0.000137122,0.0001134127,0.0002953708,0.0003110049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000176183,"about_ca_system_score_gemma":0.0000785006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662974,"about_ca_topic_score_gemma":0.000207458,"domain_scores_codex":[0.9999117,0.00001241531,0.000006454612,0.00002170096,0.0000265611,0.00002115701],"domain_scores_gemma":[0.9999377,0.00001021894,0.00001094387,0.00001152376,0.0000103783,0.00001928576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008116742,0.00001765485,0.0005886683,0.000009000926,0.000003134532,0.0002288023,0.00001610543,0.00006752028,0.9970006,0.0002076784,0.00004491326,0.001734738],"study_design_scores_gemma":[0.0001412583,0.001222346,0.01462937,0.000008702618,0.00005530837,0.007368928,0.00008054946,0.004722415,0.9620258,0.0005111938,0.009219772,0.00001434206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967996,0.0006294912,0.001645288,0.00005334312,0.00001414628,0.00001603542,0.00008331542,0.0000155332,0.0007432234],"genre_scores_gemma":[0.9970245,0.0001941728,0.001604029,0.00004440907,0.00002169223,0.00001238794,0.0003016978,0.000007319544,0.0007897848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007517439,"threshold_uncertainty_score":0.00251478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01474615803368741,"score_gpt":0.2116170537736572,"score_spread":0.1968708957399699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}