{"id":"W2068600199","doi":"10.1074/jbc.m010584200","title":"Molecular Basis for the Susceptibility of Fibrin-bound Thrombin to Inactivation by Heparin Cofactor II in the Presence of Dermatan Sulfate but Not Heparin","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University Medical Centre","funders":"","keywords":"Thrombin; Heparin cofactor II; Dermatan sulfate; Chemistry; Fibrin; Heparin; Antithrombin; Biochemistry; Ternary complex; Heparan sulfate; Immunology; Enzyme; Platelet; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142793,0.0001974514,0.00009515241,0.0001569605,0.0000940802,0.0002329086,0.0002082731,0.0002423356,0.001027396],"category_scores_gemma":[0.0001919994,0.0001131266,0.0001450069,0.00009144916,0.0001831663,0.0001004497,0.0001447851,0.0002327017,0.0002775794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243078,"about_ca_system_score_gemma":0.0001379587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007003833,"about_ca_topic_score_gemma":0.0002501319,"domain_scores_codex":[0.9999102,0.0000190956,0.00000997987,0.00001501935,0.00002547302,0.00002009907],"domain_scores_gemma":[0.9998581,0.00002251061,0.00003778921,0.00002037053,0.0000182535,0.0000429531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006301492,0.00001621607,0.0004298635,0.0000119072,0.000003792845,0.00005974411,0.000007566345,0.00003311968,0.9985716,0.000195324,0.00001376133,0.000594107],"study_design_scores_gemma":[0.00001330058,0.0001458737,0.02149892,0.000004081601,0.00001485571,0.0005015253,0.00001611645,0.00085534,0.9760381,0.0001540873,0.0007537422,0.000004155072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956553,0.0009829064,0.00182369,0.00008506532,0.00001491129,0.00001601449,0.0001065728,0.00002611932,0.001289381],"genre_scores_gemma":[0.9988882,0.0001953869,0.0004157547,0.00001654443,0.000003639796,0.000006570235,0.000104593,0.00000311897,0.0003661765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027396,"threshold_uncertainty_score":0.003437042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03149397882036378,"score_gpt":0.3033195347873954,"score_spread":0.2718255559670316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}