{"id":"W2068617028","doi":"10.1371/journal.pbio.0020219","title":"A Focused and Efficient Genetic Screening Strategy in the Mouse: Identification of Mutations That Disrupt Cortical Development","year":2004,"lang":"en","type":"article","venue":"PLoS Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Mental Health; University of California, San Francisco; National Institutes of Health","keywords":"Biology; Mutant; Genetic screen; Mutagenesis; Cerebral cortex; Corticogenesis; Genetics; Mutation; Neuroscience; Cortex (anatomy); Forebrain; Allele; Gene; Embryonic stem cell; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008671497,0.0016817,0.0007318209,0.002527437,0.0004987436,0.0005527899,0.001399586,0.00116193,0.002010623],"category_scores_gemma":[0.0006369295,0.0008734047,0.0009024071,0.0006026401,0.0007154458,0.0005513474,0.001000837,0.001582518,0.001463661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605158,"about_ca_system_score_gemma":0.0006174846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007546738,"about_ca_topic_score_gemma":0.001908298,"domain_scores_codex":[0.9993328,0.0001116005,0.00008912481,0.0001648518,0.0002193931,0.00008210462],"domain_scores_gemma":[0.9994494,0.0001250895,0.0001328175,0.0001119902,0.0000621662,0.0001184519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000370717,0.00004125813,0.0001089792,0.00003299958,0.0000128074,0.0001339708,0.00001555386,0.00009097784,0.9959655,0.0003904013,0.0001278635,0.003042585],"study_design_scores_gemma":[0.00008361394,0.0006018032,0.003348335,0.00003560672,0.00009367229,0.002686122,0.00002250454,0.00210634,0.9844929,0.0004256041,0.006069731,0.00003383135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4946649,0.002973173,0.4834509,0.001200349,0.0002237189,0.001923876,0.003462716,0.00527004,0.006830395],"genre_scores_gemma":[0.5615653,0.006529891,0.4103786,0.0009052439,0.0000770082,0.00208536,0.004264957,0.001072332,0.01312118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527437,"threshold_uncertainty_score":0.006726146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03273800814584765,"score_gpt":0.2955848092342949,"score_spread":0.2628468010884473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}