{"id":"W2068619092","doi":"10.1038/nature13683","title":"Inflammatory caspases are innate immune receptors for intracellular LPS","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2214,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of British Columbia; Tsinghua University; National Key Research and Development Program of China; Howard Hughes Medical Institute","keywords":"Innate immune system; Caspase; Receptor; Intracellular; Cell biology; Immune system; Inflammation; Immune receptor; Apoptosis; Biology; Immunology; Programmed cell death; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006316867,0.0006437773,0.000336065,0.0006354547,0.0002845351,0.001032681,0.0004064096,0.0007850904,0.002370714],"category_scores_gemma":[0.000615393,0.0002381372,0.000340776,0.0002669066,0.0007449949,0.001285443,0.0005074464,0.001358632,0.0009198893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000603771,"about_ca_system_score_gemma":0.0002493171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008156677,"about_ca_topic_score_gemma":0.00007418602,"domain_scores_codex":[0.9996015,0.0001048233,0.00004425377,0.00006803966,0.0001087091,0.00007269793],"domain_scores_gemma":[0.9995664,0.00006472644,0.0001737144,0.00004852509,0.00008025783,0.0000663727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00104478,0.00006316707,0.001308722,0.0002964128,0.00002376778,0.0007709016,0.00008710515,0.0003617075,0.9604761,0.01340158,0.0009409743,0.02122478],"study_design_scores_gemma":[0.0001317864,0.0005688626,0.009019158,0.00007858404,0.00004537045,0.007569433,0.0001708467,0.001812662,0.9174012,0.01685275,0.04631044,0.00003884254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7027578,0.1404775,0.1217168,0.01020221,0.002267893,0.0003237254,0.002146702,0.0009162546,0.01919115],"genre_scores_gemma":[0.9539448,0.01854938,0.01606289,0.0007728694,0.0003327794,0.000097526,0.00082472,0.00005038756,0.009364671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370714,"threshold_uncertainty_score":0.007930815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00303833343496352,"score_gpt":0.2130092418197969,"score_spread":0.2099709083848334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}