{"id":"W2068620877","doi":"10.1016/j.ydbio.2014.01.012","title":"Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development","year":2014,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; Frizzled; Biology; Cell biology; Bone morphogenetic protein; Zebrafish; Retina; Ectoderm; Eye development; Beta-catenin; Signal transduction; Optic cup (embryology); Anatomy; Embryo; Phenotype; Neuroscience; Embryogenesis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003267553,0.0002387033,0.0002404528,0.00009250594,0.00018146,0.00001802088,0.0001083426,0.0002153613,0.00003636763],"category_scores_gemma":[0.00004659549,0.0002279373,0.00003329922,0.00008527577,0.0002157484,0.000008636393,0.0002252932,0.00009289477,0.000008526321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003834759,"about_ca_system_score_gemma":0.0001128573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001983166,"about_ca_topic_score_gemma":0.000008513282,"domain_scores_codex":[0.9986257,0.00008077666,0.0003726788,0.0005054008,0.0001116585,0.0003037679],"domain_scores_gemma":[0.9995439,0.00002459218,0.0001486156,0.00009373778,0.00008547876,0.0001036671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003315277,0.00001952672,0.0883313,0.00003385728,0.0001349044,0.000001313211,0.0004453639,0.000001935041,0.9039664,0.0002918171,0.00002952785,0.006412553],"study_design_scores_gemma":[0.0006952241,0.0003131769,0.2439847,0.00005179181,0.00001607063,0.00005180277,0.0001503728,0.000002579443,0.751214,0.0001887597,0.003021919,0.000309574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979135,0.0004001471,0.0006130561,0.00003694062,0.0001449806,0.0001553254,0.000003866595,0.00001726143,0.0007149687],"genre_scores_gemma":[0.9943935,0.00006896588,0.004782343,0.0001319066,0.00008354409,0.00002734114,0.000127913,0.0000221785,0.0003623047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1556534,"threshold_uncertainty_score":0.9295012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004111738998526349,"score_gpt":0.2007426265570777,"score_spread":0.1966308875585514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}