{"id":"W2068688235","doi":"10.1182/blood-2003-12-4260","title":"Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"Angiogenesis; P70-S6 Kinase 1; Biology; Protein kinase B; Cell biology; Kinase; PI3K/AKT/mTOR pathway; Molecular biology; Phosphatidylinositol; Phosphorylation; Signal transduction; Biochemistry; Chemistry; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009901063,0.000391664,0.00017845,0.0001109158,0.0001305727,0.0002011668,0.0001482288,0.0001770028,0.0007465055],"category_scores_gemma":[0.0001117815,0.0001165411,0.0002336586,0.00009929711,0.0002538532,0.0001917899,0.0001982823,0.0003839226,0.0003576171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002664177,"about_ca_system_score_gemma":0.0001569805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002142881,"about_ca_topic_score_gemma":0.0003270741,"domain_scores_codex":[0.9998972,0.00001976369,0.00001170032,0.00002444975,0.00002631381,0.00002050184],"domain_scores_gemma":[0.9999123,0.0000131264,0.00003620737,0.00001189757,0.000005952767,0.00002052723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008540149,0.00001676679,0.0002074943,0.00002664567,0.000004993875,0.00004404006,0.000006078232,0.00008750547,0.9981849,0.00008254961,0.0000303814,0.001223205],"study_design_scores_gemma":[0.000009537182,0.00008523234,0.001098739,0.00000197646,0.000004742087,0.0003087949,0.000005752604,0.0004980563,0.9956778,0.00002659003,0.0022804,0.000002384421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859955,0.001615091,0.01039485,0.0001256105,0.0000326245,0.00004971939,0.0003399033,0.0001173688,0.001329288],"genre_scores_gemma":[0.9906771,0.0007494446,0.005990671,0.00004863657,0.00000885274,0.00003346318,0.0006963941,0.00002485174,0.001770492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007465055,"threshold_uncertainty_score":0.002497375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369943391818943,"score_gpt":0.2338503251063761,"score_spread":0.2201508911881866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}