{"id":"W2068700927","doi":"10.1038/nrg2481","title":"Plasma lipoproteins: genetic influences and clinical implications","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":465,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials","funders":"","keywords":"Biology; Plasma lipoprotein; Computational biology; Genetic architecture; Disease; Genome-wide association study; Genetics; Genetic association; Lipoprotein; Genetic variants; Whole genome sequencing; Bioinformatics; Genome; Evolutionary biology; Gene; Quantitative trait locus; Genotype; Internal medicine; Medicine; Cholesterol; Single-nucleotide polymorphism; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0006075961,0.0006787341,0.003871073,0.000206393,0.00009687811,0.00005409901,0.0003766522,0.001826798,0.00002970844],"category_scores_gemma":[0.0008295732,0.000455424,0.001025021,0.0006026921,0.0001881177,0.00003427275,0.0001129144,0.001901096,0.0001689223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003268577,"about_ca_system_score_gemma":0.0005289178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002026038,"about_ca_topic_score_gemma":0.00000716376,"domain_scores_codex":[0.9961341,0.0003728802,0.001929672,0.0008691638,0.0002946173,0.0003995802],"domain_scores_gemma":[0.9971999,0.0001807486,0.0007699319,0.001278466,0.0001390887,0.0004318859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002240145,0.00008899083,0.0002329056,0.01086493,0.0001000353,0.000003739723,0.000004906952,3.24866e-8,1.766501e-7,0.00009876542,0.003245149,0.9853581],"study_design_scores_gemma":[0.0003706218,0.0001679081,0.002659085,0.009607728,0.005252306,0.0002256243,0.000001195487,0.000001101496,1.897986e-7,0.0001212608,0.9811847,0.0004083205],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000286172,0.9944358,0.00001579948,0.0002563359,0.0004429219,0.004015685,0.00003828721,0.00005446299,0.0007120693],"genre_scores_gemma":[0.000002545572,0.9837905,0.01275951,0.001292285,0.00153772,0.0001857628,0.0001183113,0.00006622656,0.0002471097],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9849498,"threshold_uncertainty_score":0.9997898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07697783634379876,"score_gpt":0.4441223737611,"score_spread":0.3671445374173012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}