{"id":"W2068713279","doi":"10.2174/138920209787581271","title":"Gene Clusters, Molecular Evolution and Disease: A Speculation","year":2009,"lang":"en","type":"article","venue":"Current Genomics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"National Institutes of Health; Gillson Longenbaugh Foundation; Dana Foundation; March of Dimes Foundation","keywords":"Biology; Epigenetics; Genetics; Chromatin; Gene; DNA methylation; CTCF; Histone; Genomic organization; Chromatin remodeling; Genome; Epigenomics; Polycomb-group proteins; Computational biology; Gene expression; Enhancer; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007062565,0.0001432652,0.00009253212,0.00003629694,0.00007002495,0.00003677564,0.000104326,0.00006313806,0.000002474762],"category_scores_gemma":[0.00002342428,0.0001594458,0.00006184544,0.00004365433,0.00003328523,0.000003424084,0.00006766475,0.00005857325,0.000005567696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000054424,"about_ca_system_score_gemma":0.00008332757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.011682e-7,"about_ca_topic_score_gemma":0.000001334672,"domain_scores_codex":[0.9992437,0.00002127368,0.0001642115,0.0003088377,0.00007642532,0.0001854937],"domain_scores_gemma":[0.9994406,0.000001742021,0.00007051372,0.0002770734,0.00003972414,0.0001703857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009891662,0.0001302602,0.002492592,0.00003575393,0.00003265714,0.000004655042,0.00005738343,0.003695464,0.9585353,0.004123195,0.0007957339,0.02999813],"study_design_scores_gemma":[0.00801489,0.001660542,0.4349642,0.0001757249,0.0006569058,0.0001884449,0.0002226225,0.2062688,0.1018577,0.08654823,0.1547192,0.004722739],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575759,0.006521579,0.03516915,0.0002072092,0.0001889002,0.0001834323,0.00003169718,0.00001200406,0.0001101094],"genre_scores_gemma":[0.9968716,0.0006674997,0.001679782,0.000137255,0.0001895895,0.000004399789,0.0004000281,0.00001525536,0.00003459354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8566776,"threshold_uncertainty_score":0.6502013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006149632942408293,"score_gpt":0.2288299787434025,"score_spread":0.2226803458009942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}