{"id":"W2068713279","doi":"10.2174/138920209787581271","title":"Gene Clusters, Molecular Evolution and Disease: A Speculation","year":2009,"lang":"en","type":"article","venue":"Current Genomics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"National Institutes of Health; Gillson Longenbaugh Foundation; Dana Foundation; March of Dimes Foundation","keywords":"Biology; Epigenetics; Genetics; Chromatin; Gene; DNA methylation; CTCF; Histone; Genomic organization; Chromatin remodeling; Genome; Epigenomics; Polycomb-group proteins; Computational biology; Gene expression; Enhancer; Repressor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003694692,0.0007557286,0.001097541,0.001347728,0.0008838384,0.002769361,0.00191634,0.006847973,0.009175581],"category_scores_gemma":[0.004166873,0.0003530831,0.0008535116,0.001179212,0.007456771,0.01225118,0.001737428,0.005223011,0.002317397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001056906,"about_ca_system_score_gemma":0.001058177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002093723,"about_ca_topic_score_gemma":0.001111886,"domain_scores_codex":[0.9994216,0.0001679954,0.00003658464,0.0001990554,0.00008993227,0.00008488858],"domain_scores_gemma":[0.9964496,0.002121004,0.0002155171,0.0002578406,0.0004742374,0.0004818744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001278922,0.0003096291,0.02076859,0.001944626,0.0005249672,0.003774116,0.00181028,0.004108847,0.007266565,0.7239331,0.07326796,0.1610124],"study_design_scores_gemma":[0.0001081915,0.0002418241,0.006382788,0.0004185689,0.0001218027,0.002460082,0.002323519,0.0033704,0.0007129507,0.8576417,0.1261096,0.0001086131],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0354916,0.258381,0.02783856,0.6506659,0.005984946,0.00004522496,0.0006425296,0.0003312061,0.02061912],"genre_scores_gemma":[0.4718642,0.2637261,0.02254249,0.1794484,0.02931971,0.0002467349,0.0007950806,0.0001464449,0.03191076],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.009175581,"threshold_uncertainty_score":0.03069532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006149632942408293,"score_gpt":0.2288299787434025,"score_spread":0.2226803458009942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}