{"id":"W2068718443","doi":"10.1038/sj.cgt.7701039","title":"Engineered CD8+ cytotoxic T cells with fiber-modified adenovirus-mediated TNF-α gene transfection counteract immunosuppressive interleukin-10-secreting lung metastasis and solid tumors","year":2007,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Cancer research; Transfection; CD8; Metastasis; Tumor necrosis factor alpha; Genetic enhancement; Interleukin 2; Medicine; Immunology; Biology; Gene; Cytokine; Immune system; Cancer; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006074056,0.0004991432,0.000446568,0.0001997379,0.0002000315,0.00008672292,0.0003530507,0.0002223898,0.0004278328],"category_scores_gemma":[0.00001255932,0.0004412487,0.0001454787,0.0003126083,0.0001849405,0.00002339472,0.00005239439,0.0003116632,0.0000120453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545382,"about_ca_system_score_gemma":0.0002530133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001024384,"about_ca_topic_score_gemma":0.0002217195,"domain_scores_codex":[0.9974942,0.000132442,0.0004618532,0.0007609887,0.0003775875,0.0007729064],"domain_scores_gemma":[0.9987251,0.00005773177,0.0001782056,0.0005483537,0.0002529478,0.0002376829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01229195,0.00008033249,0.00008414131,0.00002947761,0.0006883615,0.00002973756,0.000454336,0.001909144,0.9703804,3.130428e-7,0.000187555,0.01386421],"study_design_scores_gemma":[0.003392298,0.002467957,0.0003863721,0.0000568092,0.00004695029,0.00003821212,0.0001032509,0.0004922063,0.990657,0.000002212189,0.001831459,0.0005252534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835671,0.01383435,0.001238629,0.00006062476,0.0001613599,0.0008070838,0.0001937336,0.00005568142,0.00008145322],"genre_scores_gemma":[0.9919273,0.006094449,0.0002365296,0.0002959004,0.0004318687,0.0001822684,0.0003201654,0.0001417497,0.000369762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02027658,"threshold_uncertainty_score":0.9998039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304731430085419,"score_gpt":0.2906203074642604,"score_spread":0.2775729931634062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}