{"id":"W2068718443","doi":"10.1038/sj.cgt.7701039","title":"Engineered CD8+ cytotoxic T cells with fiber-modified adenovirus-mediated TNF-α gene transfection counteract immunosuppressive interleukin-10-secreting lung metastasis and solid tumors","year":2007,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; Cancer research; Transfection; CD8; Metastasis; Tumor necrosis factor alpha; Genetic enhancement; Interleukin 2; Medicine; Immunology; Biology; Gene; Cytokine; Immune system; Cancer; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002739057,0.0006686772,0.000344608,0.0002865392,0.0001639542,0.0003845431,0.0002960742,0.0004634736,0.0009654054],"category_scores_gemma":[0.0001679651,0.0002285481,0.0003158675,0.0001370877,0.0004083455,0.0003509535,0.0001812751,0.0009193736,0.0003780486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035959,"about_ca_system_score_gemma":0.0002498311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006055736,"about_ca_topic_score_gemma":0.000635973,"domain_scores_codex":[0.9997804,0.00003574327,0.00002142451,0.00004784935,0.00004479659,0.00006973981],"domain_scores_gemma":[0.9998432,0.00003771553,0.00003765436,0.00002747338,0.00001724182,0.00003661229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001568243,0.00007278749,0.0001039548,0.00002143196,0.000005466043,0.0000336973,0.00001830109,0.0001074904,0.9981565,0.0001389971,0.00002240137,0.001162079],"study_design_scores_gemma":[0.00004881156,0.0004109778,0.000444242,0.000002630504,0.0000190064,0.0001567128,0.00001068981,0.001186326,0.9968488,0.00003621598,0.0008328041,0.000002829015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927368,0.0004849137,0.005399032,0.00007549627,0.00008531978,0.00006428076,0.00007653167,0.000157218,0.0009204379],"genre_scores_gemma":[0.9930368,0.0002795906,0.00428255,0.00003147966,0.00002412793,0.00004212002,0.0001362388,0.00002678902,0.00214027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009654054,"threshold_uncertainty_score":0.003229618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01304731430085419,"score_gpt":0.2906203074642604,"score_spread":0.2775729931634062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}