{"id":"W2068757386","doi":"10.1371/journal.ppat.1004767","title":"Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer","year":2015,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Aids Fonds; National Institutes of Health; International AIDS Vaccine Initiative","keywords":"Epitope; Trimer; Gp41; Antigen; Subdominant; Epitope mapping; Binding site; Antibody; Plasma protein binding; Biology; Virology; Chemistry; Cell biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004265886,0.0002539667,0.0001044079,0.0003233212,0.0001005817,0.0001775639,0.0001647871,0.0001670366,0.0009811368],"category_scores_gemma":[0.00006540997,0.00009487607,0.0001779702,0.0001919744,0.00007399533,0.0001512016,0.0001181602,0.0002422421,0.0003798675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001917459,"about_ca_system_score_gemma":0.0001947661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009920227,"about_ca_topic_score_gemma":0.0009233764,"domain_scores_codex":[0.9999624,0.000003939948,0.000002342459,0.000008127584,0.00001627714,0.00000678907],"domain_scores_gemma":[0.9999673,0.000004893241,0.000007852946,0.000003228546,0.000006897109,0.000009746855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004215263,0.00001155762,0.0002811568,0.00002307328,0.000002204232,0.00007279289,0.00001025315,0.0001269584,0.9978725,0.00007589942,0.00002765542,0.001453796],"study_design_scores_gemma":[0.00002800009,0.000715432,0.04448396,0.00002372865,0.0000642326,0.002677708,0.0001011661,0.008644959,0.9344285,0.0005036108,0.008312789,0.00001605576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869046,0.001557052,0.00753725,0.00007283155,0.000004537535,0.0000465524,0.0007348122,0.00005110977,0.003091158],"genre_scores_gemma":[0.9710401,0.002055217,0.01954605,0.0001598353,0.00001554891,0.00003227135,0.004252731,0.00002611451,0.002872041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009920227,"threshold_uncertainty_score":0.003282189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06476474176685411,"score_gpt":0.2760494437054538,"score_spread":0.2112847019385997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}