{"id":"W2068775998","doi":"10.1002/art.20714","title":"Inhibition of interleukin‐1β–induced cyclooxygenase 2 expression in human synovial fibroblasts by 15‐deoxy‐Δ<sup>12,14</sup>‐prostaglandin J<sub>2</sub> through a histone deacetylase–independent mechanism","year":2005,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital du Sacré-Cœur de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Trichostatin A; Chromatin immunoprecipitation; Histone deacetylase; Acetylation; Histone; Molecular biology; Histone deacetylase inhibitor; Cyclooxygenase; Chemistry; Biology; Cancer research; Gene expression; Cell biology; Promoter; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893534,0.0004703893,0.0002658331,0.0001400258,0.0001343326,0.0002502984,0.0001132392,0.000127594,0.001399212],"category_scores_gemma":[0.00008243063,0.0001334388,0.0003634648,0.0001405881,0.0002136507,0.0001098231,0.000129949,0.0003695102,0.0004850328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193913,"about_ca_system_score_gemma":0.0002845934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008045017,"about_ca_topic_score_gemma":0.001230932,"domain_scores_codex":[0.9998502,0.00002317833,0.00002095743,0.00002501335,0.00004092542,0.00003974383],"domain_scores_gemma":[0.9999281,0.0000144701,0.00001917338,0.000011297,0.00001054901,0.00001641742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002428487,0.00006775315,0.0001780746,0.00007130198,0.000007296881,0.00004495669,0.00001993518,0.00004156379,0.9974022,0.00002399952,0.00004742426,0.001852789],"study_design_scores_gemma":[0.0001137821,0.00139341,0.006757972,0.0000119101,0.00002525741,0.0002911515,0.00004559752,0.0005195081,0.9877728,0.0000267013,0.003035796,0.000006204814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876347,0.007563987,0.002080926,0.0001487353,0.000113659,0.00005481581,0.0006425701,0.0000772662,0.001683425],"genre_scores_gemma":[0.9893789,0.004173908,0.002672239,0.00009970548,0.00004154769,0.00009166223,0.0009000856,0.00001198366,0.002630029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399212,"threshold_uncertainty_score":0.004680872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00789949957600939,"score_gpt":0.2401626916762525,"score_spread":0.2322631921002431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}