{"id":"W2068788937","doi":"10.1038/sj.bjp.0704457","title":"Assessing the emetic potential of PDE4 inhibitors in rats","year":2002,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Zaprinast; Pharmacology; Chemistry; Rolipram; Xylazine; Phosphodiesterase inhibitor; Aminophylline; Phosphodiesterase; Endocrinology; Ketamine; Medicine; Anesthesia; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000517635,0.001252734,0.0007893649,0.0009766272,0.0002399597,0.0003440873,0.0004559151,0.0008160535,0.002177513],"category_scores_gemma":[0.0005081326,0.0004103051,0.0006355243,0.000362138,0.0007273198,0.0007773567,0.0003528725,0.001881135,0.0005549869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005293826,"about_ca_system_score_gemma":0.0004710084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007881994,"about_ca_topic_score_gemma":0.001414939,"domain_scores_codex":[0.9995989,0.00005903299,0.00002843172,0.00008441035,0.00007602545,0.0001531924],"domain_scores_gemma":[0.9992995,0.00008957968,0.0002326347,0.0000667073,0.00009173803,0.0002198292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005961775,0.001165442,0.0007094562,0.0001236879,0.00004619058,0.0001791779,0.00007700387,0.0002351039,0.98492,0.0001572063,0.0001593465,0.006265638],"study_design_scores_gemma":[0.0003326979,0.04090552,0.009597732,0.00001861265,0.000183402,0.0003319427,0.0001604172,0.001080304,0.9450755,0.0001377314,0.002149693,0.00002649449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908,0.003225995,0.002785556,0.0002312512,0.0001084559,0.0001759577,0.0007325705,0.0001823318,0.001758004],"genre_scores_gemma":[0.9746652,0.007523813,0.005271072,0.0003402848,0.0001791931,0.0005141178,0.001437724,0.00005937496,0.01000929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177513,"threshold_uncertainty_score":0.007284462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01310321596455183,"score_gpt":0.2849727749419598,"score_spread":0.271869558977408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}