{"id":"W2068799914","doi":"10.1038/sj.onc.1204471","title":"Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Retinoblastoma protein; Retinoblastoma; Cancer research; Cyclin D1; Estrogen receptor; Cell cycle; Cell growth; Tumor suppressor gene; Carcinogenesis; Cancer; Breast cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000229206,0.0001613076,0.0002913042,0.0001154593,0.00007322118,0.000007859879,0.00008805414,0.0001578637,0.00005213166],"category_scores_gemma":[0.000134499,0.0001052349,0.00005704298,0.00060967,0.0001225377,0.0001046397,0.00005653437,0.0002239268,1.616002e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003936352,"about_ca_system_score_gemma":0.0002696418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00151802,"about_ca_topic_score_gemma":0.0005867652,"domain_scores_codex":[0.9984197,0.0002682456,0.0004317178,0.000266826,0.0004439252,0.0001696114],"domain_scores_gemma":[0.9988986,0.00002336143,0.000539681,0.0002717599,0.0002234898,0.00004307182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001404662,0.0002178777,0.05143815,0.0000314891,0.00004240178,0.000003070256,0.0005154753,0.0006025947,0.9450856,0.0000107494,0.0000154826,0.0006324842],"study_design_scores_gemma":[0.002521286,0.0001248897,0.3862885,0.001263578,0.00003493596,0.00001671734,0.00004941344,0.0008059005,0.6087961,0.00003109845,0.000001723824,0.00006588395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974304,0.00004724539,0.00002838158,0.0005260375,0.00002069885,0.001779715,0.0001064923,0.0000115047,0.00004946705],"genre_scores_gemma":[0.9995078,0.000009608842,0.0001332335,0.00004821856,0.00004729253,0.000132255,0.00005049914,0.00002641718,0.00004462475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362895,"threshold_uncertainty_score":0.4291353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006453044169682687,"score_gpt":0.2328856203975226,"score_spread":0.2264325762278399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}