{"id":"W2068799914","doi":"10.1038/sj.onc.1204471","title":"Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Biology; Retinoblastoma protein; Retinoblastoma; Cancer research; Cyclin D1; Estrogen receptor; Cell cycle; Cell growth; Tumor suppressor gene; Carcinogenesis; Cancer; Breast cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039976,0.0002323727,0.0002216919,0.0005556933,0.0002093205,0.0002974856,0.0001365891,0.0001912188,0.001734518],"category_scores_gemma":[0.0002232364,0.000220785,0.0001518002,0.0002604473,0.000235387,0.00009826774,0.0001241493,0.0003492196,0.0005775787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002773947,"about_ca_system_score_gemma":0.0002018069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001218282,"about_ca_topic_score_gemma":0.001260189,"domain_scores_codex":[0.9999232,0.00001178498,0.00000564625,0.00001105674,0.00002966229,0.00001858902],"domain_scores_gemma":[0.9998727,0.00002977276,0.00003269637,0.00001512291,0.00001631397,0.00003343566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004626188,0.00003502194,0.002400645,0.00003040864,0.00001053362,0.000558797,0.00001818183,0.00004162216,0.9943635,0.00009162811,0.000178147,0.00180888],"study_design_scores_gemma":[0.00008173449,0.0005439789,0.2007906,0.0000071477,0.00008189351,0.01082764,0.00009413146,0.000716604,0.7808092,0.0001622014,0.005873149,0.00001163963],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949312,0.002782311,0.0006967302,0.00009737092,0.00002341958,0.000006297633,0.0002624025,0.00006831692,0.001132011],"genre_scores_gemma":[0.9946378,0.0009924691,0.0004057512,0.00003746511,0.00001596614,0.000008944997,0.0007422136,0.00001777484,0.003141476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001734518,"threshold_uncertainty_score":0.005802572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006453044169682687,"score_gpt":0.2328856203975226,"score_spread":0.2264325762278399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}