{"id":"W2068810679","doi":"10.1128/mcb.21.1.61-72.2001","title":"Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Protein kinase R; Biology; RNA silencing; RNase P; Interferon; Transcription (linguistics); EIF-2 kinase; RNA; Cell biology; Viral replication; Innate immune system; Virology; Virus; Molecular biology; Kinase; Protein kinase A; RNA interference; Gene; Immune system; Genetics; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002943394,0.0001484654,0.0001998893,0.0000398966,0.0000443331,0.00001221287,0.0001725244,0.0001165876,0.000002891697],"category_scores_gemma":[0.00002469539,0.0000977577,0.00007175303,0.0001680387,0.0004970398,0.000007465015,0.00004528565,0.0000750408,1.660324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002783743,"about_ca_system_score_gemma":0.00004599756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001233072,"about_ca_topic_score_gemma":0.00001877832,"domain_scores_codex":[0.9989411,0.000216011,0.0003070693,0.0002578348,0.000100479,0.0001775448],"domain_scores_gemma":[0.9993914,0.00001574978,0.000211271,0.0002673621,0.00007365767,0.00004054004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004319452,0.0001344263,0.007365742,0.00003754389,0.00002824102,0.000006430105,0.00006236941,0.00001177433,0.9861969,0.0009988272,0.000004385287,0.004721382],"study_design_scores_gemma":[0.001758955,0.0002667448,0.001304663,0.00002924151,0.00001869312,0.000008713245,0.0001666607,0.0001332965,0.9952174,0.0007698149,0.0002117984,0.000114027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958165,0.001819792,0.001382482,0.0001611426,0.000012156,0.0005258822,0.00001479282,0.00000301763,0.0002641865],"genre_scores_gemma":[0.999471,0.000146709,0.0001312269,0.00004493521,0.00001098601,0.00003046953,0.0001146049,0.000007857867,0.0000421866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009020459,"threshold_uncertainty_score":0.3986443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272986597438576,"score_gpt":0.2598360484977469,"score_spread":0.2471061825233612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}