{"id":"W2068810679","doi":"10.1128/mcb.21.1.61-72.2001","title":"Activation of NF-κB by Double-Stranded RNA (dsRNA) in the Absence of Protein Kinase R and RNase L Demonstrates the Existence of Two Separate dsRNA-Triggered Antiviral Programs","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation; University of Ottawa","funders":"National Institute of Environmental Health Sciences; National Cancer Institute","keywords":"Protein kinase R; Biology; RNA silencing; RNase P; Interferon; Transcription (linguistics); EIF-2 kinase; RNA; Cell biology; Viral replication; Innate immune system; Virology; Virus; Molecular biology; Kinase; Protein kinase A; RNA interference; Gene; Immune system; Genetics; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002558059,0.0006826851,0.0002942131,0.0002031149,0.0001561891,0.0003834051,0.000233417,0.0003380579,0.001345619],"category_scores_gemma":[0.0002556581,0.0001603719,0.0002593614,0.0001385759,0.0005511393,0.000446142,0.0002385822,0.00066195,0.0006702058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002653747,"about_ca_system_score_gemma":0.0001874641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001102839,"about_ca_topic_score_gemma":0.0001604655,"domain_scores_codex":[0.9998266,0.00003036443,0.00001551859,0.0000503462,0.00005129789,0.00002594598],"domain_scores_gemma":[0.9997645,0.00007047461,0.00007825746,0.00003052356,0.00001932974,0.00003688514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007526261,0.00001944272,0.0001108567,0.00006462698,0.000003587282,0.00005970917,0.000009278216,0.00002418078,0.9982571,0.0002079695,0.00001248235,0.001155669],"study_design_scores_gemma":[0.00002444276,0.0003778237,0.001894633,0.00001978273,0.00001267786,0.0008991124,0.00001875263,0.0004614382,0.9919233,0.000530143,0.003830742,0.000007069629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9206639,0.02861721,0.03983656,0.0005251988,0.0002678034,0.00009573835,0.0004163387,0.0002932872,0.009283993],"genre_scores_gemma":[0.9710292,0.008821482,0.01609219,0.0001359367,0.00007751521,0.00007321119,0.0005340143,0.0000241114,0.003212203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001345619,"threshold_uncertainty_score":0.004501522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272986597438576,"score_gpt":0.2598360484977469,"score_spread":0.2471061825233612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}